Lovastatin in Aspergillus terreus: Fermented Rice Straw Extracts Interferes with Methane Production and Gene Expression in Methanobrevibacter smithii

Figure 2

Methanogenesis pathway in M. smithii. M. smithii is able to use the Methyl H₄MPT in the middle step of methanogenesis pathway for production of acetyl-CoA and biosynthesis reactions. Enzymes and genes encode: formate dehydrogenase (fdh); formyl-MF dehydrogenase (fwd); MFN, methanofuran; ribofuranosylaminobenzene 5_-phosphate (RFA-P); ribofuranosylaminobenzene 5_-phosphate synthase (rfaS); 5-phospho-a-D-ribosyl-1-pyrophosphate (PRPP); formyl-MF: H₄MPT formyltransferase (ftr); tetrahydromethanopterin (H₄MPT); methenyl-H₄MPT cyclohydrolase (mch); methylene-H₄MPT dehydrogenase (hmd); methylene-H₄MPT reductase (mer); methyl-H₄MPT: HS-CoM methyltransferase (mtr); alcohol dehydrogenase (Adh); F420-dependent NADP oxidoreductase (fno); methanol : cobalamin methyltransferase (mtaB); methyl CoM Reductase (mcr) (modified from Hendrickson et al. [14]).