Serum Proteome Analysis in Patients with Rheumatoid Arthritis Receiving Therapy with Tocilizumab: An Anti-Interleukin-6 Receptor Antibody

Table 3

Proteins identified to increase after tocilizumab treatment.

Protein name	Accession no.	Times of detection	Relative abundance (average)				Increase ratio		Paired t-test P
			ctr	Before	4W	8W	4W/before	8W/before	Before versus 4W	Before versus 8W
Apolipoprotein A-I preproprotein	4557321	7	1	0.942	1.632	1.529	1.502	1.515	0.111	0.040
Superoxide dismutase 3, extracellular precursor	118582275	7	1	1.218	1.672	1.806	1.442	1.509	0.046	0.046
Sex hormone-binding globulin isoform 1 precursor	7382460	7	1	1.496	2.061	2.337	1.376	1.510	0.013	0.027
Lymphatic vessel endothelial hyaluronan receptor 1	40549451	5	1	1.299	1.713	1.994	1.340	1.505	0.028	0.037
ABI gene family, member 3 (NESH) binding protein	33667044	5	1	1.143	1.629	1.875	1.403	1.603	0.036	0.049
Apolipoprotein C-II precursor	32130518	7	1	1.092	1.777	1.811	1.637	1.591	0.044	0.032
Chitobiase, di-N-acetyl-	4758092	5	1	0.793	1.062	1.219	1.350	1.564	0.020	0.011
Lysosomal-associated membrane protein 1	112380628	5	1	1.417	1.648	2.239	1.220	1.581	0.017	0.037
Selectin L precursor	4506875	5	1	1.022	1.389	1.753	1.371	1.674	0.006	0.035
Retinol-binding protein 4, plasma precursor	55743122	7	1	1.150	1.797	1.920	1.607	1.637	0.016	0.041
Cysteine-rich secretory protein 3	5174675	7	1	0.799	1.224	1.325	1.529	1.685	0.002	0.004
Melanoma cell adhesion molecule	71274107	7	1	1.265	1.758	2.153	1.375	1.705	0.009	0.000
Afamin precursor	4501987	7	1	0.962	1.491	1.676	1.574	1.733	0.004	0.010
Apolipoprotein A-II preproprotein	4502149	7	1	0.770	1.433	1.363	1.822	1.745	0.017	0.008
Apolipoprotein C-I precursor	4502157	5	1	1.008	1.880	1.975	1.869	1.896	0.010	0.039
Fumarylacetoacetate hydrolase	4557587	4	1	1.022	1.836	1.966	1.965	2.087	0.155	0.038

Accession number: accession number (gi) in the human RefSeq protein database of the National Center for Biotechnology Information, USA.
Times of detection: the number of samples in which the protein was detected.
Relative abundance: the ratio of the iTRAQ reporter ion to the 114 reporter ion (control).
Increase ratio: the ratio of protein abundance between the second and first samples (4W/before) and between the third and first samples (8W/before).
Bold: increased by more than 1.5-fold.
Paired t-test P: the P value of a paired t-test between the first and second samples (4W) or between the first and third samples (8W).
Bold: 𝑃<0.05.