Cerebral Activation during Von Frey Filament Stimulation in Subjects with Endothelin-1-Induced Mechanical Hyperalgesia: A Functional MRI Study

Table 1

Regions of cerebral activations during nonpainful stimulation of the noninjected arm.

Lobus	Gyrus	Side	Talairach			BA	𝑡max	Lowest P value
			x	y	z
Innocuous mechanical stimulation
Frontal lobe	Pre-central	Ipsilateral	−42	−10	55	4	3.4	0.0051
Frontal lobe		Contralateral	21	−42	56	5	6.4	0.0000000228
Frontal lobe		Contralateral	1	−6	60	6	4.4	0.0001
Frontal lobe		Contralateral	51	1	30	6	4.2	0.00034
Frontal lobe		Ipsilateral	−54	1	24	6	7.4	2.78𝑒−09
Frontal lobe		Ipsilateral	−13	52	31	9	6.4	9.78𝑒−09
Frontal lobe		Contralateral	40	42	8	46	4.8	0.000002
Frontal lobe	Middle frontal	Ipsilateral	−41	44	5	46	6	0.000001
Frontal lobe	Middle frontal	Ipsilateral	−43	38	1	47	5.2	0.000002
Frontal lobe		Contralateral	52	5	14	44	5.6	0.00000021
Frontal lobe	Inferior frontal	Ipsilateral	−53	5	14	44	6.9	0.000000022
Parietal lobe		Contralateral	42	−59	40	40	4	0.0014
Parietal lobe		Ipsilateral	−55	−26	37	2	4.8	0.00032
Parietal lobe		Ipsilateral	−36	−62	35	39	5	0.000011
Parietal lobe		Ipsilateral	−57	−20	20	40	6.8	0.0000000021
Temporal lobe		Ipsilateral	−15	36	42	8	5.5	0.000004
Temporal lobe		Contralateral	41	−61	4	37	5.8	0.000002
Temporal lobe		Contralateral	53	0	5	22	5.6	0.00024
Occipital lobe		Contralateral	29	−83	12	19	4.9	0.000011
Occipital lobe		Contralateral	24	−90	−5	18	5.7	0.00000021
Occipital lobe		Ipsilateral	−41	−67	−1	37	4	0.0027
Occipital lobe	Middle occipital	Ipsilateral	−26	−85	14	19	5.4	0.000002
Occipital lobe	Middle occipital	Ipsilateral	−28	−87	2	18	6.6	0.000000022
Limbic lobe		Contralateral	14	−39	−6	30	5	0.000011
Insula		Contralateral	43	−34	22	13	6.9	1.2𝑒−11
Insula	Sublobar	Ipsilateral	−49	−38	20	13	3.6	0.001
Amygdala		Ipsilateral	−22	−7	−10		3.6	0.0023
Limbic lobe		Contralateral	6	−6	45	24	4.9	1.1𝑒−05
Limbic lobe		Ipsilateral	−10	−7	42	24	3.2	1.2𝑒−03