Clinical Study
Cerebral Activation during Von Frey Filament Stimulation in Subjects with Endothelin-1-Induced Mechanical Hyperalgesia: A Functional MRI Study
Table 2
Regions of cerebral activations during painful stimulation of the ET-1 injected arm.
| Lobus | Gyrus | Side | Talairach | BA | | lowest P value | x | y | z |
| Noxious mechanical stimulation
| Frontal lobe | | Ipsilateral | 60 | 3 | 24 | 6 | 5.9 | | Frontal lobe | | Contralateral | −2 | −4 | 60 | 6 | 4.2 | 0.00005 | Frontal lobe | | Contralateral | −50 | −3 | 41 | 6 | 8.9 | | Frontal lobe | | Contralateral | −16 | 46 | 36 | 8 | 5.8 | | Frontal lobe | | Contralateral | −11 | 56 | 30 | 9 | 6.8 | 0.000000209 | Frontal lobe | | Ipsilateral | 50 | 41 | 8 | 46 | 5.6 | 0.000002 | Frontal lobe | | Contralateral | −41 | 34 | 16 | 46 | 6.2 | 0.0000000228 | Frontal lobe | | Contralateral | −44 | 22 | 2 | 47 | 7 | | Frontal lobe | | Ipsilateral | 58 | 9 | 13 | 44 | 6.4 | 0.0000000228 | Frontal lobe | | Contralateral | −51 | 1 | 19 | 44 | 11.7 | | Frontal lobe | | Ipsilateral | 9 | 52 | 30 | 9 | 3.9 | 0.00068 | Frontal lobe | | Ipsilateral | 5 | 16 | 52 | 8 | 2.9 | 0.0039 | Parietal lobe | | Contralateral | −54 | −25 | 38 | 2 | 9.6 | | Parietal lobe | | Ipsilateral | 50 | −43 | 43 | 40 | 4.3 | 0.000064 | Parietal lobe | | Contralateral | −45 | −26 | 20 | 40 | 13.5 | | Parietal lobe | | Ipsilateral | 49 | −61 | 32 | 39 | 5.4 | 0.000001 | Parietal lobe | | Ipsilateral | 55 | −21 | 30 | 2 | 6.1 | 0.00000015 | Temporal lobe | | Contralateral | −65 | −27 | 5 | 22 | 7.3 | | Temporal lobe | | Ipsilateral | 45 | −61 | 4 | 37 | 6.8 | | Temporal lobe | | Contralateral | −46 | −65 | 3 | 37 | 7.8 | | Temporal lobe | | Contralateral | −49 | −62 | 24 | 39 | 7.9 | | Temporal lobe | | Ipsilateral | 67 | −32 | 6 | 22 | 7.1 | | Occipital lobe | | Ipsilateral | 34 | −89 | 9 | 19 | 2.9 | 0.0094 | Occipital lobe | | Contralateral | −35 | −89 | 7 | 19 | 3.5 | 0.003 | Occipital lobe | | Contralateral | −27 | −85 | −7 | 18 | 3.9 | 0.00034 | Occipital lobe | | Ipsilateral | 33 | −89 | 1 | 18 | 3.6 | 0.00035 | Amygdala | | Contralateral | −27 | −2 | −10 | | 5.1 | 0.000005 | Limbic lobe | | Ipsilateral | 16 | −39 | −8 | 30 | 3.4 | 0.0093 | Limbic lobe | | Ipsilateral | 5 | −6 | 45 | 24 | 4.1 | 0.000082 | Limbic lobe | | Contralateral | −12 | −3 | 47 | 24 | 3.1 | 0.0011 | Insula | | Ipsilateral | 44 | −35 | 21 | 13 | 8 | | Insula | | Contralateral | −46 | −26 | 20 | 13 | 13.3 | |
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