Cerebral Activation during Von Frey Filament Stimulation in Subjects with Endothelin-1-Induced Mechanical Hyperalgesia: A Functional MRI Study

Table 3

Regions of significantly different activation patterns after ET-1 injection.

(a) Bilateral activation after ET-1 versus unilateral activation after innocuous stimulation

Lobus	BA	Lowest P value
Parietal lobe	2	0.005
Frontal lobe	8	0.007
Frontal lobe	9	0.0013
Temporal lobe	22	0.002
Temporal lobe	39	0.023

(b) Unilateral activation after ET-1 versus no activation after innocuous stimulation

Lobus	BA	Lowest P value
Parietal lobe	2	0.0004
Frontal lobe (PMC)	6	0.02
Frontal lobe	9	0.008
Insula	13	0.004
Occipital lobe	18	0.01
Temporal lobe	37	0.01
Frontal lobe	44	0.04
Frontal lobe	46	0.0005
Frontal lobe	47	0.0004
Amygdala		0.03