Enhanced Transdermal Delivery of Diclofenac Sodium via Conventional Liposomes, Ethosomes, and Transfersomes

Table 1

Composition, particle size, polydispersity index (PDI), zeta potential, and encapsulation efficiency percent (EE%) of prepared vesicles.

Formulation	Phospholipid (mg/mL)	Cholesterol (mg/mL)	Span 80 (mg/mL)	Particle size (nm)	PDI	Zeta potential (mV)	EE%
Liposome	100	30	—	152 ± 21.3	0.37	−39.2 ± 3.9	42.61 ± 3.62
Ethosome	100	30	—	202 ± 20.6	0.34	−41.2 ± 2.1	51.72 ± 4.36
Transfersome	100	30	30	145 ± 6.6	0.11	−38.9 ± 4.1	46.73 ± 5.21