Research Article
Enhanced Transdermal Delivery of Diclofenac Sodium via Conventional Liposomes, Ethosomes, and Transfersomes
Table 2
Stability of prepared vesicles during storage at 4°C and 25°C for three months.
| Formulation (code) | Particle size (nm) | Zeta potential (mV) | EE% | Initial | After 3 months | Initial | After 3 months | Initial | After 3 months |
| Liposomal dispersion (F3) | | | | | | | 4°C | 152 ± 21.3 | 193 ± 23.6 | −39.2 ± 3.9 | −40.2 ± 2.1 | 42.61 ± 3.62 | 36.2 ± 1.9 | 25°C | 152 ± 21.3 | 219 ± 16.4 | −39.2 ± 3.9 | −36.1 ± 0.9 | 42.61 ± 3.62 | 32.1 ± 2.6 | Ethosomal dispersion (F4) | | | | | | | 4°C | 202 ± 20.6 | 235 ± 30.1 | −41.2 ± 2.1 | −42.3 ± 1.2 | 51.72 ± 4.36 | 44.6 ± 1.8 | 25°C | 202 ± 20.6 | 266 ± 8.6 | −41.2 ± 2.1 | −39.2 ± 3.1 | 51.72 ± 4.36 | 39.9 ± 3.2 | Transfersomal dispersion (F5) | | | | | | | 4°C | 145 ± 6.6 | 189 ± 9.5 | −38.9 ± 4.1 | −36.2 ± 1.1 | 46.73 ± 5.21 | 42.3 ± 0.9 | 25°C | 145 ± 6.6 | 223 ± 19.2 | −38.9 ± 4.1 | −39.2 ± 0.8 | 46.73 ± 5.21 | 35.2 ± 1.1 | Liposomal gel (F6) | | | | | | | 4°C | 152 ± 21.3 | 169 ± 10.2 | −39.2 ± 3.9 | −39.9 ± 3.2 | 42.61 ± 3.62 | 39.5 ± 1.0 | 25°C | 152 ± 21.3 | 182 ± 12.0 | −39.2 ± 3.9 | −37.2 ± 2.5 | 42.61 ± 3.62 | 38.2 ± 2.6 | Ethosomal gel (F7) | | | | | | | 4°C | 202 ± 20.6 | 221 ± 16.2 | −41.2 ± 2.1 | −40.2 ± 1.9 | 51.72 ± 4.36 | 46.8 ± 2.4 | 25°C | 202 ± 20.6 | 230 ± 20.0 | −41.2 ± 2.1 | −41.1 ± 1.2 | 51.72 ± 4.36 | 44.1 ± 1.7 | Transfersomal gel (F8) | | | | | | | 4°C | 145 ± 6.6 | 186 ± 9.2 | −38.9 ± 4.1 | −35.2 ± 2.9 | 46.73 ± 5.21 | 43.6 ± 2.6 | 25°C | 145 ± 6.6 | 196 ± 11.1 | −38.9 ± 4.1 | −38.9 ± 3.1 | 46.73 ± 5.21 | 40.3 ± 1.1 |
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