Obesity, Insulin Resistance, and Metabolic Syndrome: A Study in WNIN/Ob Rats from a Pancreatic Perspective

Table 1

Correlation matrix of anthropometric versus physiological parameters.

		Body weights	Pancreas weights	HOMA-IR	QUICKI	FPG	FPI	Plasma TBARS	Tissue TBARS	Tissue insulin	Islet size	Apoptotic index
Body weights	Pearson correlation	1
	Sig. (2-tailed)	.
Pancreas weights	Pearson correlation	0.700**	1
	Sig. (2-tailed)	0.000	.
HOMA-IR	Pearson correlation	0.893**	0.501**	1
	Sig. (2-tailed)	0.000	0.000	.
QUICKI	Pearson correlation	—	—	—	1
		0.678**	0.372**	0.765**
	Sig. (2-tailed)	0.000	0.006	0.000	.
FPG	Pearson correlation	0.339*	0.123	0.431**	—	1
					0.397**
	Sig. (2-tailed)	0.012	0.376	0.001	0.003	.
FPI	Pearson correlation	0.884**	0.494**	0.995**	—	0.408**	1
					0.751**
	Sig. (2-tailed)	0.000	0.000	0.000	0.000	0.002	.
Plasma TBARS	Pearson correlation	0.818**	0.837**	0.626**	—	0.294*	0.601**	1
					0.519**
	Sig. (2-tailed)	0.000	0.000	0.000	0.000	0.031	0.000	.
Tissue TBARS	Pearson correlation	0.917**	0.821**	0.669**	—	0.178	0.658**	0.874**	1
					0.482**
	Sig. (2-tailed)	0.000	0.000	0.000	0.000	0.199	0.000	0.000	.
Tissue insulin	Pearson correlation	0.812**	0.827**	0.710**	—	0.221	0.702**	0.778**	0.800**	1
					0.572**
	Sig. (2-tailed)	0.000	0.000	0.000	0.000	0.108	0.000	0.000	0.000	.
Islet size	Pearson correlation	0.765**	0.700**	0.749**	—	0.275*	0.725**	0.696**	0.699**	0.702**	1
					0.549**
	Sig. (2-tailed)	0.000	0.000	0.000	0.000	0.044	0.000	0.000	0.000	0.000	.
Apoptotic index	Pearson correlation	0.924**	0.554**	0.971**	—	0.367**	0.964**	0.657**	0.745**	0.733**	0.760**	1
					0.736**
	Sig. (2-tailed)	0.000	0.000	0.000	0.000	0.006	0.000	0.000	0.000	0.000	0.000	.

The table shows the correlation analysis between metabolic health parameters and physiological parameters and demonstrates a strong correlation of HOMA-IR and QUICKI with body weights, pancreas weights, plasma and tissue insulin levels, and plasma and tissue TBARS levels (𝑛=54). The table also shows the correlation analysis for other metabolic and physiological parameters (𝑛=54). FBG: fasting blood glucose, FPI: fasting plasma insulin, HOMA-IR: homeostasis model of assessment for insulin, QUICKI: quantitative insulin sensitivity check index, TBARS: thiobarbituric acid reacting species.  
**Correlation is significant at the 0.01 level (2-tailed).
*Correlation is significant at the 0.05 level (2-tailed).