Modulation of Pineal Melatonin Synthesis by Glutamate Involves Paracrine Interactions between Pinealocytes and Astrocytes through NF-𝜿B Activation

Figure 3

(a) Ablation of the inhibitory glutamatergic effect on melatonin synthesis by the TACE inhibitor BB1101. Pinealocytes and astrocytes were maintained in co-culture and stimulated with norepinephrine (NE 1 μM) in association with glutamate (Glu 600 μM) and BB1101 (10 μM). One-way ANOVA, Bonferroni multiple comparison test, ^∗∗𝑃<0.01 versus NE 1 μM, ^∗𝑃<0.05 versus NE 1 μM + Glu 600 μM, 𝑛=4 for each group, 3 experiments.