Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice
Table 2
Cancer incidence in DMBA wild-type and heterozygote mice induced groups.
Cancer topography
Heterozygote (Cx43+/−)
Wild-type (Cx43+/+)
Odds ratio (95% IC)1
Relative risk (95% IC)1
value
Mammary gland
36
27
1.128
1.067
0.7285
(0.5708−2.230)
(0.7399−1.538)
Lymphoid tissue
32
26
0.9732
0.9846
0.9380
(0.4902−1.932)
(0.6662−1.455)
Digestive tract
20
16
1.000
1.000
1.0000
(0.4640−2.155)
(0.5694−1.756)
Lung
21
7
2.944
2.400
0.0200*
(1.155−7.506)
(1.094−5.264)
Skin
10
9
0.8718
0.8889
0.7820
(0.3296−2.306)
(0.3859−2.047)
Ovary
10
3
2.923
2.667
0.1436
(0.7664−11.150)
(0.7678−9.262)
Total
75
60
—
—
—
Values calculated using wild-type mice (Cx43+/−) cancer incidence for reference to compare with cancer incidence with heterozygote group (Cx43+/+). Results of value less than 5%.
