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Figure 3: hnRNPs in r15-LOX mediated mitochondria degradation during erythoid differentiation and maturation. hnRNP K functions as a switch for r15-LOX and c-Src gene expression in the early phase of erythoid differentiation, the former is an important mediator regulating erythoid differentiation and erythrocyte maturation and the latter is a tyrosine kinase that phosphorylates hnRNP K activity and forms a feedback loop to regulate r15-LOX gene expression during the late phase of erythoid differentiation or erythrocyte maturation. Importantly, hnRNP K itself is cleaved and inactivated by caspase-3 during erythoid progenitor cell differentiation.