Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation

Figure 5

Roles of hnRNPs in the impaired granulocytic differentiation of BCR/ABL transformed myeloid progenitor cells. Both hnRNP E2 and FUS function as the downstream regulators of BCR/ABL oncoprotein and have been implicated in chronic myelogenous leukemia by preventing granulocytic differentiation from myeloid progenitor cells through inhibiting G-CSFR and blocking G-CSF signaling, which finally disrupt the normal myeloid cell differentiation or maturation pathway, resulting in myeloid progenitor cell accumulation abnormally in the bone marrow and circulation.