Table 1: hnRNPs in maintenance of stem cell self-renewal and development potency.

hnRNPsStem cell typesFunctional contextTarget geneRNA/DNA interactionReference

hnRNP I/PTBEmbryonic stem cellsProliferation
(G2/M progression)
CDK11(p58)mRNA translation[5053]
hnRNP I/nPTB Neuronal progenitor cellsCell survival(Not identified)Splicing of exons[54]
hnRNP A1/Hrp38Germline stem cellsStaying in niche undifferentiated stateDE-cadherinmRNA translation[55, 56]
hnRNP A2/B1Embryonic stem cellsProliferation, pluripotency
(G1/S transition)
(Not identified)(Not identified)[5759]
hnRNP U/AUF1Embryonic stem cellsCell pluripotencyOCT4Transcription[60]
EWSHematopoietic stem cellsCell senescence p16INK4a(Not identified)[61, 62]
FUSHematopoietic stem cellsCell survival, repopulation(Not identified)DNA repair[63]