The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening
Figure 4
Effect of indomethacin treatment on pain and paw edema/tumor growth induced by the Ehrlich tumor cells. Mice received the 1 × 106 Ehrlich tumor cells or saline, and on the 8th day, they were treated with indomethacin (0.7–6 mg/kg, i.p.) or Tris buffer. (a) The intensity of mechanical hyperalgesia, (b) thermal hyperalgesia, and (c) paw edema/tumor growth was evaluated 3 h after the treatment. Mice received the 1 × 107 Ehrlich tumor cells or saline, and on 8th day, they were treated with indomethacin (6 mg/kg i.p.) or Tris buffer, and (d) overt pain was assessed 3 h after treatment; , representative of two experiments. * vehicle group compared with the saline.
