The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening
Figure 5
Effect of amitriptyline treatment on pain and paw edema/tumor growth induced by the Ehrlich tumor cells. Mice received the 1 × 106 Ehrlich tumor cells or saline, and they were treated with amitriptyline (3–30 mg/kg, p.o.) or water every day after subcutaneous injection of tumor cells. (a) The intensity of mechanical hyperalgesia, (b) thermal hyperalgesia, and (c) paw edema/tumor growth was evaluated 3 h after the treatment on days 2, 4, 6, 8, 10, and 12 after injection of the cells. Mice received the 1 × 107 Ehrlich tumor cells or saline and were treated daily with amitriptyline (30 mg/kg, p.o.) or water and after 8 days; (d) the overt pain was assessed 3 h after the treatment; , representative of two experiments. * compared with the saline.
