Ultradeep Pyrosequencing of Hepatitis C Virus Hypervariable Region 1 in Quasispecies Analysis

Figure 2

Amino acid sequences of HVR1 populations inferred after the application of three different error correction methods. (a) Cut-off method >1% (I), (b) bidirectional coverage (II), and (c) ShoRAH computation (III). Top sequence corresponds to reference sequence AJ406073 for genotype 1b HCV. Dots indicate consensus positions. Dashes indicate positions not present in the sequence. Asterisks indicate stop codons.