Research Article
Ultradeep Pyrosequencing of Hepatitis C Virus Hypervariable Region 1 in Quasispecies Analysis
Table 2
The impact of haplotype reconstruction method on the variability parameters of HVR1.
| | Correction method | I
Cut-off 1% | II
Bidirectional coverage | III
ShoRAH |
| | Number of haplotypes | 8 | 40 | 186 | | Number of nucleotide substitutions within HVR1 | 51 | 59 | 70 | | Percentage of mutated amino acid positions within HVR1 (%) | 55.6 | 55.6 | 74.1 | | Genetic distance | 3.874 | 0.065 | 0.110 | | Genetic diversity | 0.923 | 0.998 | 0.984 |
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