Research Article
Modulation of the Rat Hepatic Cytochrome P4501A Subfamily Using Biotin Supplementation
Table 1
Evaluation of the mutagenicity of the S9 fraction that was obtained from rats that were treated with biotin in the Ames test.
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The mean number of revertant colonies identified in three replicates in two independent experiments. (b)The liver S9 fraction from control rats. (c)The liver S9 fraction from biotin-treated rats (2 mg/kg). (d)The liver S9 fraction from phenobarbital-treated rats (60 mg/kg). -naphthoflavone (80 mg/kg) was used as a positive control. (e)The slope at the origin was calculated using the SALANAL software program. *Significantly different from B− and B+ (), as assessed using Student’s -test. |