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Figure 4: Conformational transition pathway and proposed catalytic mechanism of ADK. Model a, substrate free ADK with an open conformation. Model b, ATP bound form of ADK with a closed LID domain. Model c, ATP and AMP bound form of ADK with a closed conformation. Model d, two ADP bound forms of ADK with a closed conformation. Model e, one ADP bound form of ADK with a closed NMP domain.