- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 632436, 10 pages
Treg Cells Induced by rSSP4 Derived from T. cruzi Amastigotes Increase Parasitemia in an Experimental Chagas Disease Model
1Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, 07360 Mexico, DF, Mexico
2Unidad de Servicios Generales, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, 07360 Mexico City, DF, Mexico
3Departments of Microbiology and Pathology, Medical Center, The Ohio State University, Colombus, OH 43210, USA
Received 7 August 2012; Revised 20 October 2012; Accepted 29 October 2012
Academic Editor: Luis I. Terrazas
Copyright © 2013 Y. Flores-García et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. Kotner and R. Tarleton, “Endogenous CD4+ CD25+ regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in mice,” Infection and Immunity, vol. 75, no. 2, pp. 861–869, 2007.
- N. V. Verbisck, S. Da-Silva, and R. A. Mortara, “Trypanosoma cruzi: amastigote polymorphism defined by monoclonal antibodies,” Brazilian Journal of Medical and Biological Research, vol. 31, no. 12, pp. 1583–1591, 1998.
- J. S. Silva, D. R. Twardzik, and S. G. Reed, “Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor β (TGF-β),” Journal of Experimental Medicine, vol. 174, no. 3, pp. 539–545, 1991.
- J. S. Silva, P. J. Morrissey, K. H. Grabstein, K. M. Mohler, D. Anderson, and S. G. Reed, “Interleukin 10 and interferon γ regulation of experimental Trypanosoma cruzi infection,” Journal of Experimental Medicine, vol. 175, no. 1, pp. 169–174, 1992.
- S. G. Reed, C. E. Brownell, D. M. Russo, J. S. Silva, K. H. Grabstein, and P. J. Morrissey, “IL-10 mediates susceptibility to Trypanosoma cruzi infection,” Journal of Immunology, vol. 153, no. 7, pp. 3135–3140, 1994.
- R. De Waal Malefyt, J. Abrams, B. Bennett, C. G. Figdor, and J. E. De Vries, “Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes,” Journal of Experimental Medicine, vol. 174, no. 5, pp. 1209–1220, 1991.
- D. F. Fiorentino, A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra, “IL-10 inhibits cytokine production by activated macrophages,” Journal of Immunology, vol. 147, no. 11, pp. 3815–3822, 1991.
- P. Zaccone, O. T. Burton, and A. Cooke, “Interplay of parasite-driven immune responses and autoimmunity,” Trends in Parasitology, vol. 24, no. 1, pp. 35–42, 2008.
- N. W. Andrews, K. Hong, E. S. Robbins, and V. Nussenzweig, “Stage-specific surface antigens expressed during the morphogenesis of vertebrate forms of Trypanosoma cruzi,” Experimental Parasitology, vol. 64, no. 3, pp. 474–484, 1987.
- M. Olivas-Rubio, S. Hernández-Martínez, P. Talamás-Rohana, V. Tsutsumi, P. A. Reyes-López, and J. L. Rosales-Encina, “cDNA cloning and partial characterization of amastigote specific surface protein from Trypanosoma cruzi,” Infection, Genetics and Evolution, vol. 9, no. 6, pp. 1083–1091, 2009.
- A. Ramos-Ligonio, A. López-Monteon, P. Talamás-Rohana, and J. L. Rosales-Encina, “Recombinant SSP4 protein from Trypanosoma cruzi amastigotes regulates nitric oxide production by macrophages,” Parasite Immunology, vol. 26, no. 10, pp. 409–418, 2004.
- M. A. Gavin, S. R. Clarke, E. Negrou, A. Gallegos, and A. Rudensky, “Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo,” Nature Immunology, vol. 3, no. 1, pp. 33–41, 2002.
- S. Kanangat, P. Blair, R. Reddy et al., “Disease in the scurfy (sf) mouse is associated with over expression of cytokine genes,” European Journal of Immunology, vol. 26, pp. 161–165, 1996.
- M. K. Levings, S. Gregori, E. Tresoldi, S. Cazzaniga, C. Bonini, and M. G. Roncarolo, “Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells,” Blood, vol. 105, no. 3, pp. 1162–1169, 2005.
- E. M. Shevach, “From vanilla to 28 flavors: multiple varieties of T regulatory cells,” Immunity, vol. 25, no. 2, pp. 195–201, 2006.
- Y. Belkaid, “Regulatory T cells and infection: a dangerous necessity,” Nature Reviews Immunology, vol. 7, no. 11, pp. 875–888, 2007.
- B. Salgado-Jiménez, M. Arce-Fonseca, L. Baylón-Pacheco, P. Talamás-Rohana, and J. L. Rosales-Encina, “Differential immune response in mice immunized with either the A, R, or C domains from TcSP protein of Trypanosoma cruzi or with the coding DNAs,” Parasite Immunology. In press.
- Y. Belkaid and K. Tarbell, “Regulatory T cells in the control of host-microorganism interactions,” Annual Review of Immunology, vol. 27, pp. 551–589, 2009.
- M. G. Roncarolo, S. Gregori, M. Battaglia, R. Bacchetta, K. Fleischhauer, and M. K. Levings, “Interleukin-10-secreting type 1 regulatory T cells in rodents and humans,” Immunological Reviews, vol. 212, pp. 28–50, 2006.
- M. Guilliams, T. Bosschaerts, M. Hérin et al., “Experimental expansion of the regulatory T cell population increases resistance to African trypanosomiasis,” Journal of Infectious Diseases, vol. 198, no. 5, pp. 781–791, 2008.
- F. S. Mariano, F. R. S. Gutierrez, W. R. Pavanelli et al., “The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection,” Microbes and Infection, vol. 10, no. 7, pp. 825–833, 2008.
- X. J. Sun, R. Li, X. Sun et al., “Unique roles of Schistosoma japonicum protein Sj16 to induce IFN-γ and IL-10 producing CD4+CD25+ regulatory T cells in vitro and in vivo,” Parasite Immunology, vol. 34, no. 8-9, pp. 430–439, 2012.
- A. O'Garra and P. Vieira, “TH1 cells control themselves by producing interleukin-10,” Nature Reviews Immunology, vol. 7, no. 6, pp. 425–428, 2007.
- Y. Flores-García, J. L. Rosales-Encina, A. R. Satoskar, and P. Talamás-Rohana, “IL-10-IFN-γ double producers CD4+ T cells are induced by immunization with an amastigote stage specific derived recombinant protein of Trypanosoma cruzi,” International Journal of Biological Sciences, vol. 7, no. 7, pp. 1093–1100, 2011.
- C. F. Anderson, M. Oukka, V. J. Kuchroo, and D. Sacks, “CD4+CD25-Foxp3- Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis,” Journal of Experimental Medicine, vol. 204, no. 2, pp. 285–297, 2007.
- D. M. Vitelli-Avelar, R. Sathler-Avelar, A. Teixeira-Carvalho et al., “Strategy to assess the overall cytokine profile of circulating leukocytes and its association with distinct clinical forms of human Chagas disease,” Scandinavian Journal of Immunology, vol. 68, no. 5, pp. 516–525, 2008.
- J. A. Fiuza, R. T. Fujiwara, J. A. S. Gomes et al., “Profile of central and effector memory T cells in the progression of chronic human Chagas disease,” PLoS Neglected Tropical Diseases, vol. 3, no. 9, article e512, 2009.
- F. F. de Araújo, D. M. Vitelli-Avelar, A. Teixeira-Carvalho et al., “Regulatory T cells phenotype in different clinical forms of chagas' disease,” PLoS Neglected Tropical Diseases, vol. 5, no. 5, article e992, 2011.
- F. F. de Araújo, R. Corrêa-Oliveira, M. O. C. Rocha et al., “ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity,” Immunobiology, vol. 217, no. 8, pp. 768–777, 2012.