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BioMed Research International
Volume 2013 (2013), Article ID 632436, 10 pages
http://dx.doi.org/10.1155/2013/632436
Research Article

Treg Cells Induced by rSSP4 Derived from T. cruzi Amastigotes Increase Parasitemia in an Experimental Chagas Disease Model

1Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, 07360 Mexico, DF, Mexico
2Unidad de Servicios Generales, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, 07360 Mexico City, DF, Mexico
3Departments of Microbiology and Pathology, Medical Center, The Ohio State University, Colombus, OH 43210, USA

Received 7 August 2012; Revised 20 October 2012; Accepted 29 October 2012

Academic Editor: Luis I. Terrazas

Copyright © 2013 Y. Flores-García et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Kotner and R. Tarleton, “Endogenous CD4+ CD25+ regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in mice,” Infection and Immunity, vol. 75, no. 2, pp. 861–869, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. N. V. Verbisck, S. Da-Silva, and R. A. Mortara, “Trypanosoma cruzi: amastigote polymorphism defined by monoclonal antibodies,” Brazilian Journal of Medical and Biological Research, vol. 31, no. 12, pp. 1583–1591, 1998. View at Scopus
  3. J. S. Silva, D. R. Twardzik, and S. G. Reed, “Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor β (TGF-β),” Journal of Experimental Medicine, vol. 174, no. 3, pp. 539–545, 1991. View at Scopus
  4. J. S. Silva, P. J. Morrissey, K. H. Grabstein, K. M. Mohler, D. Anderson, and S. G. Reed, “Interleukin 10 and interferon γ regulation of experimental Trypanosoma cruzi infection,” Journal of Experimental Medicine, vol. 175, no. 1, pp. 169–174, 1992. View at Publisher · View at Google Scholar · View at Scopus
  5. S. G. Reed, C. E. Brownell, D. M. Russo, J. S. Silva, K. H. Grabstein, and P. J. Morrissey, “IL-10 mediates susceptibility to Trypanosoma cruzi infection,” Journal of Immunology, vol. 153, no. 7, pp. 3135–3140, 1994. View at Scopus
  6. R. De Waal Malefyt, J. Abrams, B. Bennett, C. G. Figdor, and J. E. De Vries, “Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes,” Journal of Experimental Medicine, vol. 174, no. 5, pp. 1209–1220, 1991. View at Scopus
  7. D. F. Fiorentino, A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra, “IL-10 inhibits cytokine production by activated macrophages,” Journal of Immunology, vol. 147, no. 11, pp. 3815–3822, 1991. View at Scopus
  8. P. Zaccone, O. T. Burton, and A. Cooke, “Interplay of parasite-driven immune responses and autoimmunity,” Trends in Parasitology, vol. 24, no. 1, pp. 35–42, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. N. W. Andrews, K. Hong, E. S. Robbins, and V. Nussenzweig, “Stage-specific surface antigens expressed during the morphogenesis of vertebrate forms of Trypanosoma cruzi,” Experimental Parasitology, vol. 64, no. 3, pp. 474–484, 1987. View at Scopus
  10. M. Olivas-Rubio, S. Hernández-Martínez, P. Talamás-Rohana, V. Tsutsumi, P. A. Reyes-López, and J. L. Rosales-Encina, “cDNA cloning and partial characterization of amastigote specific surface protein from Trypanosoma cruzi,” Infection, Genetics and Evolution, vol. 9, no. 6, pp. 1083–1091, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Ramos-Ligonio, A. López-Monteon, P. Talamás-Rohana, and J. L. Rosales-Encina, “Recombinant SSP4 protein from Trypanosoma cruzi amastigotes regulates nitric oxide production by macrophages,” Parasite Immunology, vol. 26, no. 10, pp. 409–418, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. M. A. Gavin, S. R. Clarke, E. Negrou, A. Gallegos, and A. Rudensky, “Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo,” Nature Immunology, vol. 3, no. 1, pp. 33–41, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Kanangat, P. Blair, R. Reddy et al., “Disease in the scurfy (sf) mouse is associated with over expression of cytokine genes,” European Journal of Immunology, vol. 26, pp. 161–165, 1996.
  14. M. K. Levings, S. Gregori, E. Tresoldi, S. Cazzaniga, C. Bonini, and M. G. Roncarolo, “Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells,” Blood, vol. 105, no. 3, pp. 1162–1169, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. E. M. Shevach, “From vanilla to 28 flavors: multiple varieties of T regulatory cells,” Immunity, vol. 25, no. 2, pp. 195–201, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Belkaid, “Regulatory T cells and infection: a dangerous necessity,” Nature Reviews Immunology, vol. 7, no. 11, pp. 875–888, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. B. Salgado-Jiménez, M. Arce-Fonseca, L. Baylón-Pacheco, P. Talamás-Rohana, and J. L. Rosales-Encina, “Differential immune response in mice immunized with either the A, R, or C domains from TcSP protein of Trypanosoma cruzi or with the coding DNAs,” Parasite Immunology. In press.
  18. Y. Belkaid and K. Tarbell, “Regulatory T cells in the control of host-microorganism interactions,” Annual Review of Immunology, vol. 27, pp. 551–589, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. M. G. Roncarolo, S. Gregori, M. Battaglia, R. Bacchetta, K. Fleischhauer, and M. K. Levings, “Interleukin-10-secreting type 1 regulatory T cells in rodents and humans,” Immunological Reviews, vol. 212, pp. 28–50, 2006.
  20. M. Guilliams, T. Bosschaerts, M. Hérin et al., “Experimental expansion of the regulatory T cell population increases resistance to African trypanosomiasis,” Journal of Infectious Diseases, vol. 198, no. 5, pp. 781–791, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. F. S. Mariano, F. R. S. Gutierrez, W. R. Pavanelli et al., “The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection,” Microbes and Infection, vol. 10, no. 7, pp. 825–833, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. X. J. Sun, R. Li, X. Sun et al., “Unique roles of Schistosoma japonicum protein Sj16 to induce IFN-γ and IL-10 producing CD4+CD25+ regulatory T cells in vitro and in vivo,” Parasite Immunology, vol. 34, no. 8-9, pp. 430–439, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. A. O'Garra and P. Vieira, “TH1 cells control themselves by producing interleukin-10,” Nature Reviews Immunology, vol. 7, no. 6, pp. 425–428, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Flores-García, J. L. Rosales-Encina, A. R. Satoskar, and P. Talamás-Rohana, “IL-10-IFN-γ double producers CD4+ T cells are induced by immunization with an amastigote stage specific derived recombinant protein of Trypanosoma cruzi,” International Journal of Biological Sciences, vol. 7, no. 7, pp. 1093–1100, 2011. View at Scopus
  25. C. F. Anderson, M. Oukka, V. J. Kuchroo, and D. Sacks, “CD4+CD25-Foxp3- Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis,” Journal of Experimental Medicine, vol. 204, no. 2, pp. 285–297, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. D. M. Vitelli-Avelar, R. Sathler-Avelar, A. Teixeira-Carvalho et al., “Strategy to assess the overall cytokine profile of circulating leukocytes and its association with distinct clinical forms of human Chagas disease,” Scandinavian Journal of Immunology, vol. 68, no. 5, pp. 516–525, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. J. A. Fiuza, R. T. Fujiwara, J. A. S. Gomes et al., “Profile of central and effector memory T cells in the progression of chronic human Chagas disease,” PLoS Neglected Tropical Diseases, vol. 3, no. 9, article e512, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. F. F. de Araújo, D. M. Vitelli-Avelar, A. Teixeira-Carvalho et al., “Regulatory T cells phenotype in different clinical forms of chagas' disease,” PLoS Neglected Tropical Diseases, vol. 5, no. 5, article e992, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. F. F. de Araújo, R. Corrêa-Oliveira, M. O. C. Rocha et al., “FOXP3+CD25highCD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity,” Immunobiology, vol. 217, no. 8, pp. 768–777, 2012. View at Publisher · View at Google Scholar · View at Scopus