Association of CILP2 and ACE Gene Polymorphisms with Cardiovascular Risk Factors in Slovak Midlife Women

Table 2

Anthropometrical, biochemical variables and blood pressure according to CILP2 genotypes in Slovak women.

Parameter	CILP2 genotype					Menopause status * CILP2
	GG	GT/TT	𝐹	𝑃^a	𝑃^b	𝑃
	𝑛=299	𝑛=31
Weight (kg)	73.35±15.61	71.97±12.05	0.303	0.583
WC (cm)	85.66±14.55	84.20±11.42	0.479	0.489
HC (cm)	104±11.11	105±8.66	0.012	0.911
BMI (kg/m^2)	27.47±5.68	26.43±4.56	1.203	0.274
WHR	0.82±0.08	0.80±0.08	1.386	0.240
GMT (µkat/L)	0.40±0.40	0.47±0.39	0.910	0.341
ALT (µkat/L)	0.33±0.20	0.37±0.23	0.949	0.331
UA (µmol/L)	255±65.55	256±67.38	0.000	0.996
TC (mmol/L)	5.45±1.05	5.10±0.83	3.629	0.058
TG (mmol/L)	1.42±0.89	1.17±0.47	2.733	0.099
	𝑛=298	𝑛=31
Bilirubin (µmol/L)	8.82±4.13	9.58±4.47	0.963	0.327
Glucose (mmol/L)	5.02±1.41	4.79±0.82	1.032	0.310
	𝑛=276	𝑛=28				𝑛=304
HDL-C (mmol/L)	1.54±0.40	1.76±0.53	7.810	0.006	0.007	0.882
LDL-C (mmol/L)	3.29±0.96	2.84±0.72	6.076	0.014	0.016	0.557
apoA1 (g/L)	1.70±0.43	1.77±0.27	0.689	0.407
apoB (g/L)	0.95±0.26	0.80±0.18	9.289	0.003	0.004	0.821
apoB-to-apoA1	0.58±0.18	0.47±0.14	10.572	0.001	0.002	0.500
TC-to-HDL-C	3.77±1.13	3.13±0.93	8.601	0.004	0.005	0.304
non-HDL-C	3.92±1.07	3.38±0.81	7.497	0.007	0.009	0.485
LDL-C-to-HDL-C	2.29±0.92	1.78±0.77	8.454	0.004	0.006	0.352
log(TG-to-HDL-C)	−0.09±0.29	−0.18±0.26	2.989	0.085
	𝑛=269	𝑛=29
sBP (mmHg)	122±17.16	126±16.07	0.956	0.329
dBP (mmHg)	79±11.54	79±10.38	0.052	0.820

WC: waist circumference; HC: hip circumference; BMI: body mass index; WHR: waist-to-hip ratio; GMT: gamma glutamyl transpeptidase, ALT: alanine aminotransferase; UA: uric acid; TC: total cholesterol; TG: triglycerides, HDL-C: high density lipoprotein cholesterol; LDL-C: low density lipoprotein; apoA1: apolipoprotein A1; apoB: apolipoprotein B; sBP: systolic blood pressure; dBP: diastolic blood pressure. Values represent mean ± SD. aAdjusted for age; badjusted for age, BMI, and WHR.