Table 1: Macroscopic arthritic scoring system used for the clinical scoring of the induced arthritis.

Arthritic scoreObservations

0No signs of arthritis
1Swelling and/or redness of the paw or one digit
2Two joints involved
3More than two joints involved
4All joints were involved with severe arthritis of entire paw and digits

The score was based on the number of joints involved, the severity, and extent of the erythema and edema of the tissue.