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BioMed Research International
Volume 2013 (2013), Article ID 641515, 7 pages
http://dx.doi.org/10.1155/2013/641515
Clinical Study

Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease

1Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil
2Sao Jose do Rio Preto Medical School (FAMERP), Center of Research in Biochemistry and Molecular Biology, NPBIM, Avenida Brigadeiro Faria Lima 5416, Vila Sao Pedro, 15090000 Sao Jose do Rio Preto, SP, Brazil
3Federal University of São Paulo (UNIFESP), 04021001 São Paulo, SP, Brazil
4Hospital de Base, 15090000 Sao Jose do Rio Preto, SP, Brazil
5Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil
6Department of Neuroscience/Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil
7Department of Molecular Biology, Sao Jose do Rio Preto Medical School—FAMERP, 15090000 Sao Jose do Rio Preto, SP, Brazil

Received 12 April 2013; Revised 7 August 2013; Accepted 19 August 2013

Academic Editor: Patrick Kehoe

Copyright © 2013 Michele L. Gregório et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. The studied polymorphism was analyzed by PCR/RFLP. The Fisher's exact test, chi-square, ANOVA, and ) were applied. The APOE3/3 genotype was prevalent in PD patients and Controls (). Both groups showed recommended values for lipid profile, with increase in the values of total cholesterol and LDLc, as well as decreased values of triglycerides in PD patients compared with Controls (). The APOE polymorphism does not distinguish PD patients from Controls, as opposed to the lipid profile alone or in association with APOE. Furthermore, a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only.