Combination of Telmisartan with Cisplatin Controls Oral Cancer Cachexia in Rats
Figure 1
Effect of cisplatin and combination of cisplatin with telmisartan on change in (a) body weight and (b) serum glucose levels. Each point represents mean ± SEM of 6 experiments from 0 to 27 weeks. Each bar represents mean ± SEM of 6 experiments analyzed at the end of 24 weeks. *Significantly different from control group (), #significantly different from cancer control group (), CON: normal control, COC: control treated with cisplatin (0.23 mg/kg), COCT: control treated with cisplatin (0.23 mg/kg) + telmisartan (5 mg/kg/day), ORN: oral cancer control, ORC: oral cancer treated with cisplatin (0.23 mg/kg), and ORCT: oral cancer treated with cisplatin (0.23 mg/kg) + telmisartan (5 mg/kg/day).
