Combination of Telmisartan with Cisplatin Controls Oral Cancer Cachexia in Rats

Table 3

Effect of cisplatin and combination of cisplatin with telmisartan on tumor markers.

Parameters	CON	COC	COCT	ORN	ORC	ORCT
Serum lactate dehydrogenase (U/l)	835.54 ±26.86	763.02 ±18.19	687.76 ±20.88	996.71 ±21.19^∗	964.62 ±25.98	832.24 ±30.05^#
Serum 𝛾-glutamyl transferase (U/l)	74.62 ±3.752	75.85 ±2.053	67.05 ±7.211	104.003 ±1.672^∗	103.32 ±3.037	78.85 ±2.995^#
Tissue reduced glutathione (𝜇g/mg protein)	0.115 ±0.005	0.121 ±0.001	0.132 ±0.003	0.088 ±0.003^∗	0.104 ±0.007	0.114 ±0.001^#
Tissue super oxide dismutase (units/mg protein)	3.59 ±0.17	2.70 ±0.168	2.72 ±0.166	4.47 ±0.094^∗	3.80 ±0.229	3.43 ±0.109^#
Tissue malondialdehyde (nmoles/mg protein)	0.084 ±0.009	0.090 ±0.004	0.138 ±0.028	0.151 ±0.007^∗	0.097 ±0.007	0.096 ±0.004^#

∗Significantly different from control group (𝑃<0.05).
#Significantly different from cancer control group (𝑃<0.05).
CON: normal control.
COC: control treated with cisplatin (0.23 mg/kg).
COCT: control treated with cisplatin (0.23 mg/kg) + telmisartan (5 mg/kg/day).
ORN: oral cancer control.
ORC: oral cancer treated with cisplatin (0.23 mg/kg).
ORCT: oral cancer treated with cisplatin (0.23 mg/kg) + telmisartan (5 mg/kg/day).