Morphogenetic Mechanisms in the Cyclic Regeneration of Hair Follicles and Deer Antlers from Stem Cells

Figure 8

Confirmation of specificity of the interactive tissue types in the organogenesis and regeneration through transplantation. (a) Reproduced with permission from [21, Figure 3B]. HFs that were generated by introduction of DP cells subepidermis of the footpad skin (m; matrix cells; dp; dermal papilla). (b) and (c) Reproduced with permission from [22, Figures 4D and 4F, resp.]. Bumps that were formed from the subcutaneously grafted AP. Note that when an impermeable membrane was inserted between the grafted AP and the overlying skin, no skin transformation nor antler growth occurred (arrow, (b)), but when the impermeable one was replaced with a semipermeable one, skin transformation and antler formation took place (arrow, (c)). (d)–(f) Reproduced with permission from [10, Figures 1E, 3F, and 2B, resp.]. Membrane insertion (arrow) between the PP and the enveloping skin (d). Note that when the membrane was inserted at the loosely attached region (proximal side of a pedicle), no antler regeneration (asterisk) occurred (e); but at the closely associated region (distal side of a pedicle), a skinless antler (asterisk) regenerated (f).