About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 652632, 12 pages
Research Article

Inflammatory and Oxidative Stress Responses of an Alveolar Epithelial Cell Line to Airborne Zinc Oxide Nanoparticles at the Air-Liquid Interface: A Comparison with Conventional, Submerged Cell-Culture Conditions

1Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85758 Neuherberg, Germany
2Joint Mass Spectrometry Center, Helmholtz Zentrum München, Ingolstaedter LandstraBe 1, 85758 Neuherberg, Germany

Received 27 August 2012; Accepted 23 November 2012

Academic Editor: Irma Rosas

Copyright © 2013 Anke-Gabriele Lenz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [17 citations]

The following is the list of published articles that have cited the current article.

  • Megan J. Osmond-McLeod, Ronald I. W. Osmond, Yalchin Oytam, Maxine J. McCall, Bryce Feltis, Alan Mackay-Sim, Stephen A. Wood, and Anthony L. Cook, “Surface coatings of ZnO nanoparticles mitigate differentially a host of transcriptional, protein and signalling responses in primary human olfactory cells,” Particle and Fibre Toxicology, vol. 10, 2013. View at Publisher · View at Google Scholar
  • Majid Aliabadi, Roya Dastjerdi, and Kourosh Kabiri, “HTCC-Modified Nanoclay for Tissue Engineering Applications: A Synergistic Cell Growth and Antibacterial Efficiency,” BioMed Research International, vol. 2013, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  • Alicja Panas, Andreas Comouth, Harald Saathoff, Thomas Leisner, Marco Al-Rawi, Michael Simon, Gunnar Seemann, Olaf Doessel, Sonja Muelhopt, Hanns-Rudolf Paur, Susanne Fritsch-Decker, Carsten Weiss, and Silvia Diabate, “Silica nanoparticles are less toxic to human lung cells when deposited at the air-liquid interface compared to conventional submerged exposure,” Beilstein Journal of Nanotechnology, vol. 5, pp. 1590–1602, 2014. View at Publisher · View at Google Scholar
  • Halina Milnerowicz, Milena Ściskalska, and Magdalena Dul, “Pro-inflammatory effects of metals in persons and animals exposed to tobacco smoke,” Journal of Trace Elements in Medicine and Biology, 2014. View at Publisher · View at Google Scholar
  • Andrea Adamcakova-Dodd, Larissa V. Stebounova, Jong Sung Kim, Sabine U. Vorrink, Andrew P. Ault, Patrick T. O'Shaughnessy, Vicki H. Grassian, and Peter S. Thorne, “Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models,” Particle and Fibre Toxicology, vol. 11, 2014. View at Publisher · View at Google Scholar
  • Abhijit Sarkar, Manoranjan Ghosh, and Parames Chandra Sil, “Nanotoxicity: Oxidative Stress Mediated Toxicity of Metal and Metal Oxide Nanoparticles,” Journal of Nanoscience and Nanotechnology, vol. 14, no. 1, pp. 730–743, 2014. View at Publisher · View at Google Scholar
  • Linda C. Stoehr, Carola Endes, Isabella Radauer-Preiml, Matthew S. P. Boyles, Eudald Casals, Sandor Balog, Markus Pesch, Alke Petri-Fink, Barbara Rothen-Rutishauser, Martin Himly, Martin J. D. Clift, and Albert Duschl, “Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle ,” Particle And Fibre Toxicology, vol. 12, 2015. View at Publisher · View at Google Scholar
  • Nicklas Raun Jacobsen, Tobias Stoeger, Sybille van den Brule, Anne Thoustrup Saber, Andrea Beyerle, Giulia Vietti, Alicja Mortensen, Józef Szarek, Hans Christian Budtz, Ali Kermanizadeh, Atrayee Banerjee, Nuran Ercal, Ulla Vogel, Håkan Wallin, and Peter Møller, “Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories,” Food and Chemical Toxicology, 2015. View at Publisher · View at Google Scholar
  • Shruti R Saptarshi, Albert Duschl, and Andreas L Lopata, “Biological reactivity of zinc oxide nanoparticles with mammalian test systems: an overview,” Nanomedicine, pp. 1–18, 2015. View at Publisher · View at Google Scholar
  • Hedwig M. Braakhuis, Samantha K. Kloet, Sanja Kezic, Frieke Kuper, Margriet V. D. Z. Park, Susann Bellmann, Meike van der Zande, Séverine Le Gac, Petra Krystek, Ruud J. B. Peters, Ivonne M. C. M. Rietjens, and Hans Bouwmeester, “Progress and future of in vitro models to study translocation of nanoparticles,” Archives of Toxicology, 2015. View at Publisher · View at Google Scholar
  • Xuefang Jing, Jae Hong Park, Thomas M. Peters, and Peter S. Thorne, “Toxicity of copper oxide nanoparticles in lung epithelial cells exposed at the air-liquid interface compared with in vivo assessment,” Toxicology in Vitro, 2015. View at Publisher · View at Google Scholar
  • Sonja Mülhopt, Marco Dilger, Silvia Diabaté, Christoph Schlager, Tobias Krebs, Ralf Zimmermann, Jeroen Buters, Sebastian Oeder, Thomas Wäscher, Carsten Weiss, and Hanns-Rudolf Paur, “Toxicity testing of combustion aerosols at the air-liquid interface with a self-contained and easy-to-use exposure system,” Journal of Aerosol Science, 2016. View at Publisher · View at Google Scholar
  • Mariola M. Marcinkiewicz, Sandy T. Baker, Jichuan Wu, Terrence L. Hubert, and Marla R. Wolfson, “A Novel Approach for Ovine Primary Alveolar Epithelial Type II Cell Isolation and Culture from Fresh and Cryopreserved Tissue Obtained from Premature ,” Plos One, vol. 11, no. 3, 2016. View at Publisher · View at Google Scholar
  • Jia Liu, Xiaoli Feng, Limin Wei, Liangjiao Chen, Bin Song, and Longquan Shao, “The toxicology of ion-shedding zinc oxide nanoparticles,” Critical Reviews in Toxicology, pp. 1–37, 2016. View at Publisher · View at Google Scholar
  • Huanhuan Jiang, Myoseon Jang, Tara Sabo-Attwood, and Sarah E. Robinson, “Oxidative Potential of Secondary Organic Aerosols Produced from Photooxidation of Different Hydrocarbons Using Outdoor Chamber under Ambient Sunlight,” Atmospheric Environment, 2016. View at Publisher · View at Google Scholar
  • Chantal Darquenne, John S. Fleming, Ira Katz, Andrew R. Martin, Jeffry Schroeter, Omar S. Usmani, Jose Venegas, and Otmar Schmid, “Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung,” Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2016. View at Publisher · View at Google Scholar
  • Rashmirekha Pati, Ishani Das, Ranjit Kumar Mehta, Rojalin Sahu, and Avinash Sonawane, “Zinc-Oxide Nanoparticles Exhibit Genotoxic, Clastogenic, Cytotoxic and Actin Depolymerization Effects by Inducing Oxidative Stress Responses in Macrophages and Adult Mice,” Toxicological Sciences, pp. kfw010, 2016. View at Publisher · View at Google Scholar