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1. H. Schulz, V. Harder, A. Ibald-Mulli et al., “Cardiovascular effects of fine and ultrafine particles,” Journal of Aerosol Medicine, vol. 18, no. 1, pp. 1–22, 2005. View at Publisher · View at Google Scholar · View at Scopus
2. R. Rückerl, A. Ibald-Mulli, W. Koenig et al., “Air pollution and markers of inflammation and coagulation in patients with coronary heart disease,” American Journal of Respiratory and Critical Care Medicine, vol. 173, no. 4, pp. 432–441, 2006. View at Publisher · View at Google Scholar · View at Scopus
3. A. Peters, H. E. Wichmann, T. Tuch, J. Heinrich, and J. Heyder, “Respiratory effects are associated with the number of ultrafine particles,” American Journal of Respiratory and Critical Care Medicine, vol. 155, no. 4, pp. 1376–1383, 1997. View at Scopus
4. T. Stoeger, C. Reinhard, S. Takenaka et al., “Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice,” Environmental Health Perspectives, vol. 114, no. 3, pp. 328–333, 2006. View at Publisher · View at Google Scholar · View at Scopus
5. R. Duffin, L. Tran, D. Brown, V. Stone, and K. Donaldson, “Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity,” Inhalation Toxicology, vol. 19, no. 10, pp. 849–856, 2007. View at Publisher · View at Google Scholar · View at Scopus
6. T. Stoeger, S. Takenaka, B. Frankenberger et al., “Deducing in vivo toxicity of combustion-derived nanoparticles from a cell-Free oxidative potency assay and metabolic activation of organic compounds,” Environmental Health Perspectives, vol. 117, no. 1, pp. 54–60, 2009. View at Publisher · View at Google Scholar · View at Scopus
7. I. Y. R. Adamson, H. Prieditis, C. Hedgecock, and R. Vincent, “Zinc is the toxic factor in the lung response to an atmospheric particulate sample,” Toxicology and Applied Pharmacology, vol. 166, no. 2, pp. 111–119, 2000. View at Publisher · View at Google Scholar · View at Scopus
8. T. B. Councell, K. U. Duckenfield, E. R. Landa, and E. Callender, “Tire-wear particles as a source of zinc to the environment,” Environmental Science and Technology, vol. 38, no. 15, pp. 4206–4214, 2004. View at Publisher · View at Google Scholar · View at Scopus
9. M. L. Sammut, J. Rose, A. Masion et al., “Determination of zinc speciation in basic oxygen furnace flying dust by chemical extractions and X-ray spectroscopy,” Chemosphere, vol. 70, no. 11, pp. 1945–1951, 2008. View at Publisher · View at Google Scholar · View at Scopus
10. J. M. Fine, T. Gordon, L. C. Chen et al., “Characterization of clinical tolerance to inhaled zinc oxide in naive subjects and sheet metal workers,” Journal of Occupational and Environmental Medicine, vol. 42, no. 11, pp. 1085–1091, 2000. View at Scopus
11. W. G. Kuschner, A. D'Alessandro, H. Wong, and P. D. Blanc, “Early pulmonary cytokine responses to zinc oxide fume inhalation,” Environmental Research, vol. 75, no. 1, pp. 7–11, 1997. View at Publisher · View at Google Scholar · View at Scopus
12. M. Lindahl, P. Leanderson, and C. Tagesson, “Novel aspect on metal fume fever: Zinc stimulates oxygen radical formation in human neutrophils,” Human and Experimental Toxicology, vol. 17, no. 2, pp. 105–110, 1998. View at Publisher · View at Google Scholar · View at Scopus
13. R. J. Vandebriel and W. H. De Jong, “A review of mammalian toxicity of ZnO nanoparticles,” vol. Nanotechnology, Science and Application, no. 5, pp. 61–71, 2012.
14. G. J. Nohynek, J. Lademann, C. Ribaud, and M. S. Roberts, “Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety,” Critical Reviews in Toxicology, vol. 37, no. 3, pp. 251–277, 2007. View at Publisher · View at Google Scholar · View at Scopus
15. A. Nel, T. Xia, L. Mädler, and N. Li, “Toxic potential of materials at the nanolevel,” Science, vol. 311, no. 5761, pp. 622–627, 2006. View at Publisher · View at Google Scholar · View at Scopus
16. G. Oberdörster, E. Oberdörster, and J. Oberdörster, “Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles,” Environmental Health Perspectives, vol. 113, no. 7, pp. 823–839, 2005. View at Publisher · View at Google Scholar · View at Scopus
17. T. Stoeger, O. Schmid, S. Takenaka, and H. Schulz, “Inflammatory response to TiO₂ and carbonaceous particles scales best with BET surface area,” Environmental Health Perspectives, vol. 115, no. 6, pp. A290–A291, 2007. View at Scopus
18. T. Stoeger and O. Schmid, Dose-Response Relationships, Informa Healthcare, London, UK, 2009.
19. K. M. Waters, L. M. Masiello, R. C. Zangar et al., “Macrophage responses to silica nanoparticles are highly conserved across particle sizes,” Toxicological Sciences, vol. 107, no. 2, pp. 553–569, 2009. View at Publisher · View at Google Scholar · View at Scopus
20. D. Shaw, Introduction to Colloid and Surface Chemistry, Butterworth Heinemann, Oxford, UK, 4th edition, 1992.
21. E. Bitterle, E. Karg, A. Schroeppel et al., “Dose-controlled exposure of A549 epithelial cells at the air-liquid interface to airborne ultrafine carbonaceous particles,” Chemosphere, vol. 65, no. 10, pp. 1784–1790, 2006. View at Publisher · View at Google Scholar · View at Scopus
22. S. Diabaté, S. Mülhopt, H. R. Paur, and H. F. Krug, “The response of a co-culture lung model to fine and ultrafine particles of incinerator fly ash at the air-liquid interface,” ATLA Alternatives to Laboratory Animals, vol. 36, no. 3, pp. 285–298, 2008. View at Scopus
23. M. Savi, M. Kalberer, D. Lang et al., “A novel exposure system for the efficient and controlled deposition of aerosol particles onto cell cultures,” Environmental Science and Technology, vol. 42, no. 15, pp. 5667–5674, 2008. View at Publisher · View at Google Scholar · View at Scopus
24. A. L. Holder, D. Lucas, R. Goth-goldstein, and C. P. Koshland, “Cellular response to diesel exhaust particles strongly depends on the exposure method,” Toxicological Sciences, vol. 103, no. 1, pp. 108–115, 2008. View at Publisher · View at Google Scholar · View at Scopus
25. M. Aufderheide and U. Mohr, “A modified CULTEX system for the direct exposure of bacteria to inhalable substances,” Experimental and Toxicologic Pathology, vol. 55, no. 6, pp. 451–454, 2004. View at Publisher · View at Google Scholar · View at Scopus
26. J. Volckens, L. Dailey, G. Walters, and R. B. Devlin, “Direct particle-to-cell deposition of coarse ambient particulate matter increases the production of inflammatory mediators from cultured human airway epithelial cells,” Environmental Science and Technology, vol. 43, no. 12, pp. 4595–4599, 2009. View at Publisher · View at Google Scholar · View at Scopus
27. B. M. Rothen-Rutishauser, S. C. Kiama, and P. Gehr, “A three-dimensional cellular model of the human respiratory tract to study the interaction with particles,” American Journal of Respiratory Cell and Molecular Biology, vol. 32, no. 4, pp. 281–289, 2005. View at Publisher · View at Google Scholar · View at Scopus
28. A. G. Lenz, E. Karg, B. Lentner et al., “A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles,” Particle and Fibre Toxicology, vol. 6, article 32, 2009.
29. K. Donaldson and C. L. Tran, “Inflammation caused by particles and fibers,” Inhalation Toxicology, vol. 14, no. 1, pp. 5–27, 2002. View at Publisher · View at Google Scholar · View at Scopus
30. T. Xia, M. Kovochich, M. Liong et al., “Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties,” ACS Nano, vol. 2, no. 10, pp. 2121–2134, 2008. View at Publisher · View at Google Scholar · View at Scopus
31. N. Li, T. Xia, and A. E. Nel, “The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles,” Free Radical Biology and Medicine, vol. 44, no. 9, pp. 1689–1699, 2008. View at Publisher · View at Google Scholar · View at Scopus
32. K. A. Foster, C. G. Oster, M. M. Mayer, M. L. Avery, and K. L. Audus, “Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism,” Experimental Cell Research, vol. 243, no. 2, pp. 359–366, 1998. View at Publisher · View at Google Scholar · View at Scopus
33. A. Tippe, U. Heinzmann, and C. Roth, “Deposition of fine and ultrafine aerosol particles during exposure at the air/cell interface,” Journal of Aerosol Science, vol. 33, no. 2, pp. 207–218, 2002. View at Publisher · View at Google Scholar · View at Scopus
34. J. M. Desantes, X. Margot, A. Gil, and E. Fuentes, “Computational study on the deposition of ultrafine particles from Diesel exhaust aerosol,” Journal of Aerosol Science, vol. 37, no. 12, pp. 1750–1769, 2006. View at Publisher · View at Google Scholar · View at Scopus
35. P. A. Baron and K. Willeke, Aerosol Measurement, Wiley-Interscience, New York, NY, USA, 2001.
36. M. Kaszuba, M. T. Connah, F. K. McNeil-Watson, and U. Nobbmann, “Resolving concentrated particle size mixtures using dynamic light scattering,” Particle and Particle Systems Characterization, vol. 24, no. 3, pp. 159–162, 2007. View at Publisher · View at Google Scholar · View at Scopus
37. O. Schmid, E. Karg, D. E. Hagen, P. D. Whitefield, and G. A. Ferron, “On the effective density of non-spherical particles as derived from combined measurements of aerodynamic and mobility equivalent size,” Journal of Aerosol Science, vol. 38, no. 4, pp. 431–443, 2007. View at Publisher · View at Google Scholar · View at Scopus
38. J. Gebhart, Optical Direct-Reading Techniques: Light Intensity Systems, Wiley Interscience, New York, NY, USA, 2001.
39. J. G. Teeguarden, P. M. Hinderliter, G. Orr, B. D. Thrall, and J. G. Pounds, “Particokinetics in vitro: Dosimetry considerations for in vitro nanoparticle toxicity assessments,” Toxicological Sciences, vol. 95, no. 2, pp. 300–312, 2007. View at Publisher · View at Google Scholar · View at Scopus
40. B. T. Smith, “Cell line A549: a model system for the study of alveolar type II cell function,” American Review of Respiratory Disease, vol. 115, no. 2, pp. 285–293, 1977. View at Scopus
41. A. W. Stadnyk, “Cytokine production by epithelial cells,” FASEB Journal, vol. 8, no. 13, pp. 1041–1047, 1994. View at Scopus
42. H. Fehrenbach, “Alveolar epithelial type II cell: defender of the alveolus revisited,” Respiratory Research, vol. 2, no. 1, pp. 33–46, 2001. View at Publisher · View at Google Scholar · View at Scopus
43. E. L. Herzog, A. R. Brody, T. V. Colby, R. Mason, and M. C. Williams, “Knowns and unknowns of the alveolus,” Proceedings of the American Thoracic Society, vol. 5, no. 7, pp. 778–782, 2008. View at Publisher · View at Google Scholar · View at Scopus
44. A. D. P. Carero, P. H. M. Hoet, L. Verschaeve, G. Schoeters, and B. Nemery, “Genotoxic effects of carbon black particles, diesel exhaust particles, and urban air particulates and their extracts on a human alveolar epithelial cell line (A549) and a human monocytic cell line (THP-1),” Environmental and Molecular Mutagenesis, vol. 37, no. 2, pp. 155–163, 2001. View at Publisher · View at Google Scholar · View at Scopus
45. E. Herzog, H. J. Byrne, A. Casey et al., “SWCNT suppress inflammatory mediator responses in human lung epithelium in vitro,” Toxicology and Applied Pharmacology, vol. 234, no. 3, pp. 378–390, 2009. View at Publisher · View at Google Scholar · View at Scopus
46. R. B. Reed, D. A. Ladner, C. P. Higgins, P. Westerhoff, and J. F. Ranville, “Solubility of nano-zinc oxide in environmentally and biologically important matrices,” Environmental Toxicology and Chemistry, vol. 31, no. 1, pp. 93–99, 2012.
47. H. R. Paur, F. R. Cassee, J. Teeguarden et al., “In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung-a dialog between aerosol science and biology,” Journal of Aerosol Science, vol. 42, no. 10, pp. 668–692, 2011. View at Publisher · View at Google Scholar · View at Scopus
48. P. M. Hinderliter, K. R. Minard, G. Orr et al., “ISDD: a computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies,” Particle and Fibre Toxicology, vol. 7, no. 1, article 36, 2010. View at Publisher · View at Google Scholar · View at Scopus
49. S. Kameyama, M. Kondo, K. Takeyama, and A. Nagai, “Air exposure causes oxidative stress in cultured bovine tracheal epithelial cells and produces a change in cellular glutathione systems,” Experimental Lung Research, vol. 29, no. 8, pp. 567–583, 2003. View at Scopus
50. F. Blank, B. M. Rothen-Rutishauser, S. Schurch, and P. Gehr, “An optimized in vitro model of the respiratory tract wall to study particle cell interactions,” Journal of Aerosol Medicine, vol. 19, no. 3, pp. 392–405, 2006. View at Publisher · View at Google Scholar · View at Scopus
51. A. J. Ross, L. A. Dailey, L. E. Brighton, and R. B. Devlin, “Transcriptional profiling of mucociliary differentiation in human airway epithelial cells,” American Journal of Respiratory Cell and Molecular Biology, vol. 37, no. 2, pp. 169–185, 2007. View at Publisher · View at Google Scholar · View at Scopus
52. W. G. Kreyling, J. J. Godleski, S. T. Kariya, R. M. Rose, and J. D. Brain, “In vitro dissolution of uniform cobalt oxide particles by human and canine alveolar macrophages,” American Journal of Respiratory Cell and Molecular Biology, vol. 2, no. 5, pp. 413–422, 1990. View at Scopus