Combined Treatment with Low Concentrations of Decitabine and SAHA Causes Cell Death in Leukemic Cell Lines but Not in Normal Peripheral Blood Lymphocytes

<table> (a) Distribution of cell cycle phases monitored by PI staining of ethanol-fixed cells: untreated (C) or treated by 1 <i>μ</i>M DAC (D), 1 <i>μ</i>M SAHA (S), or DAC + SAHA combination (DS). Data are averaged from at least three experiments. (b) Expression of cyclin-dependent kinase inhibitor p21WAF1 after 48 h of 1 <i>μ</i>M DAC and/or 1 <i>μ</i>M SAHA treatment of leukemic cell lines (CML-T1, HL-60) or PBL. Images are representatives of at least five experiments.</table>

BioMed Research International

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Figure 4: Combined Treatment with Low Concentrations of Decitabine and SAHA Causes Cell Death in Leukemic Cell Lines but Not in Normal Peripheral Blood Lymphocytes 

Figure 4 | Combined Treatment with Low Concentrations of Decitabine and SAHA Causes Cell Death in Leukemic Cell Lines but Not in Normal Peripheral Blood Lymphocytes 