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BioMed Research International
Volume 2013 (2013), Article ID 674378, 11 pages
In Vivo Caprine Model for Osteomyelitis and Evaluation of Biofilm-Resistant Intramedullary Nails
1Department of Orthopaedic Surgery, Alpert Medical School, Brown University, Suite 200, 2 Dudley Street, Providence, RI 02905, USA
2Weiss Center for Orthopaedic Trauma Research, Rhode Island Hospital, Providence, RI 02903, USA
3BioIntraface Inc., North Kingstown, RI 02852, USA
4Department of Pathobiology, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
Received 2 April 2013; Accepted 17 May 2013
Academic Editor: Florence Siepmann
Copyright © 2013 Nhiem Tran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. A. Hayda, M. T. Mazurek, E. T. Powell IV et al., “From Iraq back to Iraq: modern combat orthopaedic care,” Instructional course lectures, vol. 57, pp. 87–99, 2008.
- C. K. Murray, J. R. Hsu, J. S. Solomkin et al., “Prevention and management of infections associated with combat-related extremity injuries,” The Journal of trauma, vol. 64, no. 3, supplement, pp. S239–S251, 2008.
- R. B. Gustilo, R. M. Mendoza, and D. N. Williams, “Problems in the management of type III (severe) open fractures: a new classification of type III open fractures,” Journal of Trauma, vol. 24, no. 8, pp. 742–746, 1984.
- R. B. Gustilo, R. P. Gruninger, and T. Davis, “Classification of type III (severe) open fractures relative to treatment and results,” Orthopedics, vol. 10, no. 12, pp. 1781–1788, 1987.
- M. J. Patzakis and J. Wilkins, “Factors influencing infection rate in open fracture wounds,” Clinical Orthopaedics and Related Research, no. 243, pp. 36–40, 1989.
- B. M. Parrett, E. Matros, J. J. Pribaz, and D. P. Orgill, “Lower extremity trauma: trends in the management of soft-tissue reconstruction of open tibia-fibula fractures,” Plastic and Reconstructive Surgery, vol. 117, no. 4, pp. 1315–1322, 2006.
- S. Rajasekaran, J. N. Babu, J. Dheenadhayalan et al., “A score for predicting salvage and outcome in Gustilo type-IIIA and type-IIIB open tibial fractures,” Journal of Bone and Joint Surgery B, vol. 88, no. 10, pp. 1351–1360, 2006.
- S. B. Naique, M. Pearse, and J. Nanchahal, “Management of severe open tibial fractures. The need for combined orthopaedic and plastic surgical treatment in specialist centres,” Journal of Bone and Joint Surgery B, vol. 88, no. 3, pp. 351–357, 2006.
- P. V. Giannoudis, C. Papakostidis, and C. Roberts, “A review of the management of open fractures of the tibia and femur,” Journal of Bone and Joint Surgery B, vol. 88, no. 3, pp. 281–289, 2006.
- R. B. Gustilo and J. T. Anderson, “Prevention of infection in the treatment of one thousand and twenty five open fractures of long bones: retrospective and prospective analyses,” Journal of Bone and Joint Surgery A, vol. 58, no. 4, pp. 453–458, 1976.
- C. Sen, L. Eralp, T. Gunes, M. Erdem, V. E. Ozden, and M. Kocaoglu, “An alternative method for the treatment of nonunion of the tibia with bone loss,” Journal of Bone and Joint Surgery B, vol. 88, no. 6, pp. 783–789, 2006.
- H. Carsenti-Etesse, F. Doyon, N. Desplaces et al., “Epidemiology of bacterial infection during management of open leg fractures,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 18, no. 5, pp. 315–323, 1999.
- J. Lee, “Efficacy of cultures in the management of open fractures,” Clinical Orthopaedics and Related Research, no. 339, pp. 71–75, 1997.
- A. G. Gristina, “Biomaterial-centered infection: microbial adhesion versus tissue integration,” Science, vol. 237, no. 4822, pp. 1588–1595, 1987.
- G. Colon, B. C. Ward, and T. J. Webster, “Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO2,” Journal of Biomedical Materials Research A, vol. 78, no. 3, pp. 595–604, 2006.
- V. Antoci Jr., C. S. Adams, J. Parvizi et al., “The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection,” Biomaterials, vol. 29, no. 35, pp. 4684–4690, 2008.
- I. Sondi and B. Salopek-Sondi, “Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria,” Journal of Colloid and Interface Science, vol. 275, no. 1, pp. 177–182, 2004.
- J. S. Kim, E. Kuk, K. N. Yu et al., “Antimicrobial effects of silver nanoparticles,” Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 3, no. 1, pp. 95–101, 2007.
- S. Shrivastava, T. Bera, A. Roy, G. Singh, P. Ramachandrarao, and D. Dash, “Characterization of enhanced antibacterial effects of novel silver nanoparticles,” Nanotechnology, vol. 18, no. 22, Article ID 225103, 2007.
- J. R. Morones, J. L. Elechiguerra, A. Camacho et al., “The bactericidal effect of silver nanoparticles,” Nanotechnology, vol. 16, no. 10, pp. 2346–2353, 2005.
- S. Pal, Y. K. Tak, and J. M. Song, “Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the gram-negative bacterium Escherichia coli,” Applied and Environmental Microbiology, vol. 73, no. 6, pp. 1712–1720, 2007.
- J. D. Jarrell, B. Dolly, and J. R. Morgan, “Controlled release of vanadium from titanium oxide coatings for improved integration of soft tissue implants,” Journal of Biomedical Materials Research A, vol. 90, no. 1, pp. 272–281, 2009.
- J. D. Jarrell, B. Dolly, and J. R. Morgan, “Rapid screening, in vitro study of metal oxide and polymer hybrids as delivery coatings for improved soft-tissue integration of implants,” Journal of Biomedical Materials Research A, vol. 92, no. 3, pp. 1094–1104, 2010.
- T. P. Schaer, S. Stewart, B. B. Hsu, and A. M. Klibanov, “Hydrophobic polycationic coatings that inhibit biofilms and support bone healing during infection,” Biomaterials, vol. 33, no. 5, pp. 1245–1254, 2012.
- S. Stewart, S. Barr, J. Engiles et al., “Vancomycin-modified implant surface inhibits biofilm formation and supports bone-healing in an infected osteotomy model in Sheep A Proof-of-Concept Study,” The Journal of Bone & Joint Surgery, vol. 94, no. 15, pp. 1406–1415, 2012.
- J. S. Hayes, D. I. Vos, J. Hahn, S. G. Pearce, and R. G. Richards, “An in vivo evaluation of surface polishing of TAN intermedullary nails for ease of removal,” European Cells and Materials, vol. 18, pp. 15–26, 2009.
- A. Kumar, P. K. Vemula, P. M. Ajayan, and G. John, “Silver-nanoparticle-embedded antimicrobial paints based on vegetable oil,” Nature Materials, vol. 7, no. 3, pp. 236–241, 2008.
- N. Tran and P. A. Tran, “Nanomaterial‐based treatments for medical device‐associated infections,” ChemPhysChem, vol. 13, no. 10, pp. 2481–2494, 2012.
- M. Kumari, A. Mukherjee, and N. Chandrasekaran, “Genotoxicity of silver nanoparticles in Allium cepa,” Science of the Total Environment, vol. 407, no. 19, pp. 5243–5246, 2009.
- L. Braydich-Stolle, S. Hussain, J. J. Schlager, and M.-C. Hofmann, “In vitro cytotoxicity of nanoparticles in mammalian germline stem cells,” Toxicological Sciences, vol. 88, no. 2, pp. 412–419, 2005.
- S. M. Hussain, K. L. Hess, J. M. Gearhart, K. T. Geiss, and J. J. Schlager, “In vitro toxicity of nanoparticles in BRL 3A rat liver cells,” Toxicology In Vitro, vol. 19, no. 7, pp. 975–983, 2005.