P-Glycoprotein-Activity Measurements in Multidrug Resistant Cell Lines: Single-Cell versus Single-Well Population Fluorescence Methods

Table 2

EC₅₀ and 𝐸_max values obtained from the doses responses curves.

	EC50 (µM)		𝐸max
	FC	MPR	FC	MPR
MCF-7/Doxo; PSC833	1,40	1,23	16,03	6,01
MCF-7/Doxo; VRP	28,29	68,04	24,59	10,39
Hs578T/Doxo; PSC833	1,83	1,40	11,99	4,48
Hs578T/Doxo; VRP	102,00	24,96	44,70	6,27

Values are given for the two methods (flow cytometry—FC and microplate reader—MPR) with the two different antagonists for the two cells lines, MCF-7/Doxo and Hs578T.