Table 2: Incidence of tumor of the IP6-treated rats with AOM-induced colon carcinogenesis.

Group no.TreatmentNo. of ratsIncidence (%) of adenoma and/or adenocarcinoma
AdenomaAdenocarcinomaTotal

1Normal6000
2AOM only64/6 (67%)a5/6 (83%)b5/6 (83%)b
3AOM + 0.2% (w/v) IP663/6 (50%)c3/6 (50%)c4/6 (67%)d
4AOM + 0.5% (w/v) IP661/6 (17%)e2/6 (33%)f3/6 (50%)g
5AOM + 1% (w/v) IP661/6 (17%)e1/6 (17%)e2/6 (33%)f

Groups: normal, AOM only, AOM + 0.2% (w/v) of IP6, AOM + 0.5% (w/v) of IP6, AOM + 1% (w/v) of IP6, and (IP6: inositol hexaphosphate, AOM: azoxymethane). Values in the same column with different superscript indicate significant difference by the Tukey’s test ( ). Adenoma is defined as a benign tumor of glandular origin. Adenocarcinoma is a malignant tumor originating in glandular epithelium. Total tumor consists of both adenoma and adenocarcinoma in the colon tumor tissue.