Microenvironment and Radiation Therapy

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Strategies</td><td align="left">Mechanisms/representative strategies or drugs</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Hyperbaric oxygen therapy</td><td align="left">Direct oxygen delivery to hypoxic regions</td></tr><tr><td align="left">Carbogen with nicotinamide</td><td align="left">Direct oxygen delivery to hypoxic regions/ARCON </td></tr><tr><td align="left">Hemoglobin modification</td><td align="left">Direct oxygen delivery to hypoxic regions</td></tr><tr><td align="left">Nitroimidazole derivatives</td><td align="left">Radiosensitization by mimicking the effect of oxygen/misonidazole</td></tr><tr><td align="left">Hypoxic cytotoxins</td><td align="left">Cell killing by hydroxyl radicals or an oxidizing radicals/tirapazamine</td></tr><tr><td align="left">HIF-1 Inhibitors</td><td align="left">Suppression of radioresistant phenotype of hypoxic tumor cells/YC-1</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>Modified figure from [<a href="/journals/bmri/2013/685308/#B17">14</a>].<br/></td></tr></table>

Strategies to overcome radioresistance of hypoxic tumor cells.

BioMed Research International

tab2

Table 2

Table 2: Microenvironment and Radiation Therapy 