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BioMed Research International
Volume 2013 (2013), Article ID 689089, 10 pages
http://dx.doi.org/10.1155/2013/689089
Research Article

Preliminary Results of Implantation in Animal Model and Osteoblast Culture Evaluation of Prototypes of Biomimetic Multispiked Connecting Scaffold for Noncemented Stemless Resurfacing Hip Arthroplasty Endoprostheses

1Department of Medical Bioengineering Fundamentals, Institute of Technology, Casimir the Great University, Karola Chodkiewicza 30, 85-064 Bydgoszcz, Poland
2Department of Process Engineering, Institute of Technology and Chemical Engineering, Poznan University of Technology, Marii Sklodowskiej-Curie 2, 60-965 Poznan, Poland
3Department of Spine Surgery, Oncologic Orthopaedics and Traumatology, Poznan University of Medical Sciences, 28 Czerwca 1956 135/147, 61-545 Poznan, Poland
4Department of Clinical Auxology, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland
5Growth Hormone & Growing Skeleton Research Group, Poznan University of Medical Sciences, 28 Czerwca 1956 135/147, 61-545 Poznan, Poland
6Department of Pharmacology, Poznan University of Medical Sciences, Rokietnicka 5A, 60-806 Poznan, Poland

Received 29 April 2013; Accepted 3 July 2013

Academic Editor: Adrian Dragu

Copyright © 2013 Ryszard Uklejewski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We present the new fixation method for RHA (resurfacing hip arthroplasty) endoprostheses by means of the biomimetic multispiked connecting scaffold (MSC-Scaffold). Such connecting scaffold can generate new type of RHA endoprostheses, that is stemless and fixed entirely without cement. The preprototypes of this MSC-Scaffold were manufactured with modern additive laser additive technology (SLM). The pilot surgical implantations in animal model (two laboratory swine) of MSC-Scaffold preprototypes have showed after two months neither implant loosening, migration, and nor other early complications. From the results of performed histopathological evaluation of the periscaffold spikes bone tissue and 10-day culture of human osteoblasts (NHOst) we can conclude that (1) the scaffolding effect was obtained and (2) to improve the osseointegration of the scaffold spikes, their material surface should be physicochemically modified (e.g., with hydroxyapatite). Some histopathological findings in the periscaffold domain near the MSC-Scaffold spikes bases (fibrous connective tissue and metallic particles near the MSC-Scaffold spikes bases edges) prompt considering the necessity to optimize the design of the MSC-Scaffold in the regions of its interspike space near the spikes bases edges, to provide more room for new bone formation in this region and for indispensable post-processing (glass pearl blasting) after the SLM manufacturing.