Table 1: Characteristics of human lung injury.

Clinical featuresAcute onset
Diffuse bilateral alveolar injury
Acute exudative phase
Repair with fibrosis

Physiological changesV/Q abnormalities
Severe hypoxemia
Decreased compliance
Impaired alveolar fluid clearance

Biological changesIncreased endothelial and epithelial permeability
Increased cytokine concentration in lungs
Protease activation
Coagulation abnormalities

Pathological changesNeutrophilic alveolar infiltrates
Intra-alveolar coagulation and fibrin deposition
Injury of the alveolar epithelium with denudation of the basement membrane