The Rabbit as a Model for Studying Lung Disease and Stem Cell Therapy

Table 1

Characteristics of human lung injury.

Clinical features	Acute onset
	Diffuse bilateral alveolar injury
	Acute exudative phase
	Repair with fibrosis
Physiological changes	V/Q abnormalities
	Severe hypoxemia
	Decreased compliance
	Impaired alveolar fluid clearance
Biological changes	Increased endothelial and epithelial permeability
	Increased cytokine concentration in lungs
	Protease activation
	Coagulation abnormalities
Pathological changes	Neutrophilic alveolar infiltrates
	Intra-alveolar coagulation and fibrin deposition
	Injury of the alveolar epithelium with denudation of the basement membrane