Role of the Plasma Membrane Transporter of Organic Cations OCT1 and Its Genetic Variants in Modern Liver Pharmacology

Figure 1

Schematic representation of carriers playing a major role in drug uptake across the sinusoidal membrane of human hepatocytes. The molecular model of the presumed OCT1 structure is also depicted. OA⁻: organic anions; OC⁺: organic cations; BA⁻: bile acids.