Role of the Plasma Membrane Transporter of Organic Cations OCT1 and Its Genetic Variants in Modern Liver Pharmacology

Table 3

Drugs transported by human OCT1.

Drug category	Typical compounds	Pharmacological action	Reference
Opioids	O-Desmethyltramadol	Analgesic	[88]
Cinchona alkaloids	Quinidine	Antiarrhythmic	[10]
Calcium channel blockers	Lamotrigine	Anticonvulsant	[89]
Dopamine antagonists	Sulpiride	Antidepressive	[90]
Serotonin antagonists	Ondansetron, tropisetron	Antiemetic	[43]
Histamine antagonists	Cimetidine	Antigastric ulcers	[91]
Fluoroquinolones	Ciprofloxacin	Antimicrobial	[92, 93]
Anthraquinones	Mitoxantrone	Antineoplastic	[7]
Camptothecin analogs	Irinotecan	Antineoplastic	[94]
Glycopeptide antibiotics	Bleomycin	Antineoplastic	[7]
Platinum compounds	Oxaliplatin, Bamet-UD2	Antineoplastic	[6, 95]
Radiopharmaceuticals	[^123I] or [^131I] m-iodobenzylguanidine	Antineoplastic	[96]
Survivin suppressants	YM 155	Antineoplastic	[97]
Taxoids	Paclitaxel	Antineoplastic	[94]
Tyrosine kinase inhibitors	Imatinib	Antineoplastic	[3, 98, 99]
	Sorafenib
Aromatic diamidines	Furamidine, pentamidine	Antiparasitic	[100]
NMDA receptor antagonists	Amantadine	Anti-Parkinsonian	[40]
Dopamine agonists	Levodopa, pramipexole	Anti-Parkinsonian	[40]
Nucleoside analogs	Acyclovir, lamivudine	Antivirals	[101, 102]
Biguanides	Metformin	Hypoglycemic	[5]
Cationic steroids	Pancuronium; Rocuronium	Neuromuscular blocking	[10]