Table 3: Drugs transported by human OCT1.

Drug categoryTypical compoundsPharmacological actionReference

OpioidsO-DesmethyltramadolAnalgesic[88]
Cinchona alkaloidsQuinidineAntiarrhythmic[10]
Calcium channel blockersLamotrigineAnticonvulsant[89]
Dopamine antagonistsSulpirideAntidepressive[90]
Serotonin antagonistsOndansetron, tropisetronAntiemetic[43]
Histamine antagonistsCimetidineAntigastric ulcers[91]
FluoroquinolonesCiprofloxacinAntimicrobial[92, 93]
AnthraquinonesMitoxantroneAntineoplastic[7]
Camptothecin analogsIrinotecanAntineoplastic[94]
Glycopeptide antibioticsBleomycinAntineoplastic[7]
Platinum compoundsOxaliplatin, Bamet-UD2Antineoplastic[6, 95]
Radiopharmaceuticals 123I or 131I m-iodobenzylguanidineAntineoplastic[96]
Survivin suppressantsYM 155Antineoplastic[97]
TaxoidsPaclitaxelAntineoplastic[94]
Tyrosine kinase inhibitorsImatinib Antineoplastic[3, 98, 99]
Sorafenib
Aromatic diamidinesFuramidine, pentamidineAntiparasitic[100]
NMDA receptor antagonistsAmantadineAnti-Parkinsonian [40]
Dopamine agonistsLevodopa, pramipexoleAnti-Parkinsonian [40]
Nucleoside analogsAcyclovir, lamivudineAntivirals[101, 102]
BiguanidesMetforminHypoglycemic[5]
Cationic steroidsPancuronium
Rocuronium
Neuromuscular blocking [10]