Table 2: A summary of information on some previous experimental validations for the accuracy of D-LBTE solvers in predicting the doses in heterogeneous humanoid phantoms using multiple clinical setup fields.

Published investigationsHan et al. 2012. [33]Kan et al. 2013 [34]Kan et al. 2012 [30]Han et al. 2013 [35]Hoffmann et al. 2012 [32]

Disease of interestOropharyngeal
tumor
Nasopharyngeal
carcinoma
Locally persistent
nasopharyngeal
carcinoma
Lung cancerTumor in mediastinum

Media involvedWater equivalent materialsTissue, air, and boneTissue, air, and boneTissue and lungTissue, lung, and bone

Treatment technique usedIMRT, VMATIMRT, VMATIMSRTIMRT, VMATA total of 11 different plans including opposing fields, multiple fields, IMRT, and VMAT.

Phantom usedRPC head and neck phantomAnthropomorphic
phantom (RANDO)
Anthropomorphic
phantom (RANDO)
RPC thorax phantomCIRS Thorax phantom

Measurement deviceTLD and EBT filmTLD and EBT filmTLDTLD and EBT filmEBT film

LBTE solverAXB version 11
using both and
AXB version 10
using both and
AXB version 10
using only
AXB version 11
using both and
AXB version 10
using only

Observed resultsFor TLD, deviation within 5%.
For gamma analysis with film,
88% passed 5%/3 mm criterion for both and
For TLD, deviation within 5%, with an average of 1.8%.
For gamma analysis with film,
91% passed 3%/3 mm criterion for and 99% for
For TLD,
deviation within 3%
For TLD, deviation within 4.4%.
For gamma analysis with film,
~97% passed 3%/3 mm criterion for and 98% for
For gamma analysis with film,
98.2% passed the 3%/3 mm criterion for 6 MV and 99.5% for 15 MV