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Figure 2: MHC1 are assembled in the lumen of the endoplasmatic reticulum where interaction with target peptides is mediated by chaperons. These peptides, cellular or viral derived, are produced in the cytosol by proteasome (1) and are transported into the ER lumen by TAP pump (2). Subsequently, the chaperon tapasin interacts with TAP, promoting the bond between peptides and HLA (3). The complex HLA peptide egresses through the golgi complex to the plasma membrane where it can remain (4) or can be released in soluble form to the extracellular space (5). ER: endoplasmic reticulum. GO: golgi apparatus.