Overexpression of RKIP Inhibits Cell Invasion in Glioma Cell Lines through Upregulation of miR-98
Figure 1
The miR-98 levels were positively correlated with the RKIP mRNA levels and negatively correlated with the HMGA2 mRNA levels in gliomas tissues. ((a), (b), (c)) The expression of RKIP mRNA, HMGA2 mRNA, and miR-98 was tested by quantitative RT-PCR in gliomas tissues compared to the adjacent normal brain tissues in a panel of matched tissues from 26 glioma patients (Wilcoxon’s paired test, values shown in the figures). ((d), (e)) Dot plots represent RKIP (HMGA2) mRNA relative expression level against miR-98 relative expression level. The lines represent approximated curves. The correlation coefficient () and the value indicate the statistical significance of the negative correlation between the and variables. Results showed that the expression of miR-98 was positively correlated with RKIP mRNA and negatively correlated with HMGA2 mRNA. The figure is representative of three experiments with similar results.
