Overexpression of RKIP Inhibits Cell Invasion in Glioma Cell Lines through Upregulation of miR-98
Figure 3
miR-98 directly targets HMGA2 by binding to its 3′UTR. (a) The predicted miR-98 binding site within HMGA2 3′UTR and its mutated version by site mutagenesis are as shown. (b) The repression of luciferase activity by HMGA2 3′UTR was dependent on miR-98 both in U251 and U87. Mutated HMGA2 3′UTR abrogated miR-98 mediated repression luciferase activity ().
