Gene Therapy of Multiple Sclerosis Using Interferon β-Secreting Human Bone Marrow Mesenchymal Stem Cells
Figure 1
In vitro and in vivo transgene expression for MSCs-IFNβ. (a) IFN-β protein production was detected in supernatants from IFN-β-transduced MSCs by ELISA. MSCs-GFP was used as a control. (b) For the quantification of secreted IFN-β and longevity of IFN-β expression in EAE, serum was isolated on different days (/each group) after treatment and then assessed by ELISA. Columns: mean; bars: SE. The results are representative of three independent experiments.
