Gene Therapy of Multiple Sclerosis Using Interferon β-Secreting Human Bone Marrow Mesenchymal Stem Cells
Figure 3
MSCs-IFNβ reduced inflammatory infiltrates and demyelination in the spinal cord of EAE mice. (a) The representative sections depicting the inflammatory infiltrates in the lumbar spinal cord of EAE mice by each treatment (/each group). Statistical results showed that MSCs-IFNβ treatment significantly reduced the number of infiltrating cells, compared to PBS- or MSCs-GFP. (b) The representative sections depicting the demyelination in the lumbar spinal cord of EAE mice by each treatment (/each group). Statistical results showed that MSCs-IFNβ treatment significantly reduced the area of demyelination, compared to PBS or MSCs-GFP treatment. The box represents areas of demyelination and infiltration. Magnification: ×200. Columns: mean; bars: SE. ** and Student’s t-test. The results are representative of three independent experiments.
