Gene Therapy of Multiple Sclerosis Using Interferon β-Secreting Human Bone Marrow Mesenchymal Stem Cells

Figure 5

MSCs-IFNβ induce neurotrophins in the cerebral cortex of EAE mice. (a) RT-PCR analysis for BDNF and NGF in the cerebral cortex of EAE mice after PBS-, MSCs-GFP, or MSCs-IFNβ treatment (𝑛=3/each group). (b) The BDNF and NGF mRNA expression was significantly induced in the brain of MSCs-IFNβ treatment group compared to the PBS- or MSCs-GFP treatment groups (𝑛=3/each group). Columns: mean; bars: SE. *𝑃<0.05; **𝑃<0.01; Student’s t-test. The results are representative of three independent experiments.

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