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BioMed Research International
Volume 2013 (2013), Article ID 696837, 11 pages
High Density Sphere Culture of Adult Cardiac Cells Increases the Levels of Cardiac and Progenitor Markers and Shows Signs of Vasculogenesis
1Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden
2Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden
3Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
Received 6 July 2012; Accepted 5 September 2012
Academic Editor: Daria Nurzynska
Copyright © 2013 Kristina Vukusic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- O. Bergmann, R. D. Bhardwaj, S. Bernard et al., “Evidence for cardiomyocyte renewal in humans,” Science, vol. 324, no. 5923, pp. 98–102, 2009.
- F. S. Loffredo, M. L. Steinhauser, J. Gannon, and R. T. Lee, “Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair,” Cell Stem Cell, vol. 8, no. 4, pp. 389–398, 2011.
- A. P. Beltrami, L. Barlucchi, D. Torella et al., “Adult cardiac stem cells are multipotent and support myocardial regeneration,” Cell, vol. 114, no. 6, pp. 763–776, 2003.
- K. Kikuchi, J. E. Holdway, A. A. Werdich et al., “Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes,” Nature, vol. 464, no. 7288, pp. 601–605, 2010.
- Y. Zhang, T. S. Li, S. T. Lee et al., “Dedifferentiation and proliferation of mammalian cardiomyocytes,” PloS one, vol. 5, no. 9, p. e12559, 2010.
- T. Pedrazzini, “Control of cardiogenesis by the notch pathway,” Trends in Cardiovascular Medicine, vol. 17, no. 3, pp. 83–90, 2007.
- A. Boni, K. Urbanek, A. Nascimbene et al., “Notch1 regulates the fate of cardiac progenitor cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 40, pp. 15529–15534, 2008.
- Y. Qyang, S. Martin-Puig, M. Chiravuri et al., “The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/β-catenin pathway,” Cell Stem Cell, vol. 1, no. 2, pp. 165–179, 2007.
- L. Lin, L. Cui, W. Zhou et al., “β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 22, pp. 9313–9318, 2007.
- C. Kwon, L. Qian, P. Cheng, V. Nigam, J. Arnold, and D. Srivastava, “A regulatory pathway involving Notch1/β-catenin/Isl1 determines cardiac progenitor cell fate,” Nature Cell Biology, vol. 11, no. 8, pp. 951–957, 2009.
- S. D. Bird, P. A. Doevendans, M. A. Van Rooijen et al., “The human adult cardiomyocyte phenotype,” Cardiovascular Research, vol. 58, no. 2, pp. 423–434, 2003.
- N. T. Elliott and F. Yuan, “A review of three-dimensional in vitro tissue models for drug discovery and transport studies,” Journal of Pharmaceutical Sciences, vol. 100, no. 1, pp. 59–74, 2011.
- R. E. Akins Jr., D. Rockwood, K. G. Robinson, D. Sandusky, J. Rabolt, and C. Pizarro, “Three-dimensional culture alters primary cardiac cell phenotype,” Tissue Engineering A, vol. 16, no. 2, pp. 629–641, 2010.
- E. Messina, L. De Angelis, G. Frati et al., “Isolation and expansion of adult cardiac stem cells from human and murine heart,” Circulation Research, vol. 95, no. 9, pp. 911–921, 2004.
- T. S. Li, K. Cheng, S. T. Lee et al., “Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair,” Stem Cells, vol. 28, no. 11, pp. 2088–2098, 2010.
- K. Tateishi, E. Ashihara, S. Honsho et al., “Human cardiac stem cells exhibit mesenchymal features and are maintained through Akt/GSK-3β signaling,” Biochemical and Biophysical Research Communications, vol. 352, no. 3, pp. 635–641, 2007.
- D. C. Andersen, P. Andersen, M. Schneider, H. B. Jensen, and S. P. Sheikh, “Murine “cardiospheres” are not a source of stem cells with cardiomyogenic potential,” Stem Cells, vol. 27, no. 7, pp. 1571–1581, 2009.
- M. Jonsson, H. B. Henriksson, M. Hagman et al., “Novel 3D culture system with similarities to the human heart for studies of the cardiac stem cell niche,” Regenerative Medicine, vol. 5, no. 5, pp. 725–736, 2010.
- A. M. Smits, P. van Vliet, C. H. Metz et al., “Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology,” Nature Protocols, vol. 4, no. 2, pp. 232–243, 2009.
- J. Sandstedt, M. Jonsson, A. Lindahl, A. Jeppsson, and J. Asp, “C-kit+ CD45- Cells found in the adult human heart represent a population of endothelial progenitor cells,” Basic Research in Cardiology, vol. 105, no. 4, pp. 545–556, 2010.
- S. Bollini, N. Smart, and P. R. Riley, “Resident cardiac progenitor cells: at the heart of regeneration,” Journal of Molecular and Cellular Cardiology, vol. 50, no. 2, pp. 296–303, 2011.
- E. C. Goldsmith, A. Hoffman, M. O. Morales et al., “Organization of fibroblasts in the heart,” Developmental Dynamics, vol. 230, no. 4, pp. 787–794, 2004.
- T. Tallheden, C. Karlsson, A. Brunner et al., “Gene expression during redifferentiation of human articular chondrocytes,” Osteoarthritis and Cartilage, vol. 12, no. 7, pp. 525–535, 2004.
- C. R. Gazoti Debessa, L. B. Mesiano Maifrino, and R. Rodrigues de Souza, “Age related changes of the collagen network of the human heart,” Mechanisms of Ageing and Development, vol. 122, no. 10, pp. 1049–1058, 2001.
- J. P. Kirton and Q. Xu, “Endothelial precursors in vascular repair,” Microvascular Research, vol. 79, no. 3, pp. 193–199, 2010.
- V. L. J. L. Thijssen, J. Ausma, and M. Borgers, “Structural remodelling during chronic atrial fibrillation: act of programmed cell survival,” Cardiovascular Research, vol. 52, no. 1, pp. 14–24, 2001.
- A. Moretti, L. Caron, A. Nakano et al., “Multipotent embryonic Isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification,” Cell, vol. 127, no. 6, pp. 1151–1165, 2006.
- L. Bu, X. Jiang, S. Martin-Puig et al., “Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages,” Nature, vol. 460, no. 7251, pp. 113–117, 2009.
- K. L. Laugwitz, A. Moretti, J. Lam et al., “Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages,” Nature, vol. 433, no. 7026, pp. 647–653, 2005.
- A. Moretti, J. Lam, S. M. Evans, and K. L. Laugwitz, “Cardiovascular development: towards biomedical applicability—biology of Isl1+ cardiac progenitor cells in development and disease,” Cellular and Molecular Life Sciences, vol. 64, no. 6, pp. 674–682, 2007.
- M. Ieda, J. D. Fu, P. Delgado-Olguin et al., “Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors,” Cell, vol. 142, no. 3, pp. 375–386, 2010.
- M. Xin, E. M. Small, E. Van Rooij et al., “Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 19, pp. 7975–7980, 2007.
- P. Cohen and M. Goedert, “GSK3 inhibitors: development and therapeutic potential,” Nature Reviews Drug Discovery, vol. 3, no. 6, pp. 479–487, 2004.
- P. H. Sugden, S. J. Fuller, S. C. Weiss, and A. Clerk, “Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis,” British Journal of Pharmacology, vol. 153, supplement 1, pp. S137–S153, 2008.