Table 1: nsSNPs analyzed by four computational methods PolyPhen 2.0, SIFT, I-Mutant 3.0, and PANTHER in TYRP1 gene.

SNP IDMutationPolyPhen 2.0SIFTI-MUTANT 3.0PANTHER
PSICPredictionScorePredictionDDGStabilitysubPSECPrediction

rs202189890S270R0.996Damaging0.18Tolerated Neutral Tolerated
rs202126779T253M0.996Damaging0.08Tolerated Decrease Deleterious
rs201899938S8F0.963Damaging0.7Tolerated Neutral Tolerated
rs201789348E139K0.301Benign0.24Tolerated Decrease Deleterious
rs201605146S470N0.134Benign0.36Tolerated Neutral Tolerated
rs201457510G63S1.000Damaging0.00Deleterious Neutral Deleterious
rs201345670M266T0.772 Damaging0.00Deleterious Decrease Deleterious
rs201293896R146W0.975Damaging0.02Deleterious Decrease Deleterious
rs200882524L487F0.998Damaging0.23Tolerated Decrease Deleterious
rs200754545W249G1.000Damaging0.00Deleterious Decrease Deleterious
rs200607153A486T0.029Benign0.05Deleterious Decrease Tolerated
rs199989943R73W0.999Damaging0.02Deleterious Neutral Deleterious
rs199823942T366M0.014Benign0.01Deleterious Decrease Tolerated
rs193035382C303G1.000Damaging0.00Deleterious Decrease Deleterious
rs188236569Y522C1.000Damaging0.01Deleterious Decrease Deleterious
rs187959351G300E1.000Damaging0.86Tolerated Decrease Deleterious
rs184910238A380S1.000Damaging0.05Deleterious Decrease Tolerated
rs183546444P476T0.000Benign1.00Tolerated Decrease Tolerated
rs182508840T275A0.064Benign0.10Tolerated Decrease Tolerated
rs181755026E524A0.001Benign0.22Tolerated Decrease Tolerated
rs151091299S305R0.992Damaging0.01Deleterious Neutral Deleterious
rs150899857R505H0.753Damaging0.07Tolerated Decrease Deleterious
rs149856598G309E0.566Damaging0.00Deleterious Decrease Deleterious
rs149324507V189L1.000Damaging0.00Deleterious Decrease Deleterious
rs148777155S498P0.761Damaging0.19Tolerated Neutral Deleterious
rs148248971A409V0.972Damaging0.01Deleterious Decrease Deleterious
rs147212712L7P0.924Damaging0.01Deleterious DecreaseNANA
rs146962444D123V0.628Damaging0.03Deleterious Neutral Deleterious
rs146838872V33A0.000Benign0.45Tolerated Decrease Tolerated
rs146467307V373I0.013Benign0.54Tolerated Decrease Tolerated
rs146027807R153C1.000Damaging0.05Tolerated Decrease Deleterious
rs144438412A67T0.001Benign0.36Tolerated Decrease Tolerated
rs144206983S207I0.968Damaging0.24Tolerated IncreaseNANA
rs143705229A31G0.159Benign0.02Deleterious Decrease Deleterious
rs143610120N132I1.000Damaging0.00Deleterious Increase Deleterious
rs143106698F383L0.999Damaging0.04Deleterious Decrease Deleterious
rs143004036N96Y0.987Damaging0.00Deleterious Neutral Deleterious
rs142019860Q520K0.067Benign0.05Tolerated Decrease Tolerated
rs141949653N435H1.000Damaging0.00Deleterious Decrease Deleterious
rs141834891R23W0.02Benign0.22Tolerated Neutral Tolerated
rs141196295R114C0.019Benign0.00Deleterious Neutral Deleterious
rs140233627S506G0.004Benign0.40Tolerated Decrease Tolerated
rs139946740G309R0.754Damaging0.00Deleterious Decrease Deleterious
rs139670838R55H0.771Damaging0.13Tolerated Decrease Deleterious
rs138272660R471W0.986Damaging0.00Deleterious Neutral Deleterious
rs138038972R125K0.000Benign0.21Tolerated Neutral Tolerated
rs121912778R374G1.000Damaging0.06Tolerated Decrease Deleterious
rs113146199D343V1.000Damaging0.00Deleterious Decrease Deleterious
rs78071458G174L0.993Damaging0.00Deleterious Decrease Deleterious
rs61758405A24T0.219Benign0.02Deleterious Decrease Deleterious
rs61752939T262M1.000Damaging0.00Deleterious Decrease Deleterious
rs61752937R93H0.998Damaging0.04Deleterious Decrease Deleterious
rs61752864A70T0.859Damaging0.09Tolerated Decrease Tolerated
rs41306053D308N0.000Benign0.70Tolerated Decrease Tolerated
rs41305647Q518H0.000Benign0.23Tolerated Decrease Tolerated
rs41305645Q530R0.029Benign0.43Tolerated Neutral Tolerated
rs41303653G485A0.000Benign1.00Tolerated Neutral Deleterious
rs41303651R505C0.861Damaging0.01Deleterious Neutral Tolerated
rs35197549V319G0.997Damaging0.01Deleterious Decrease Deleterious
rs16929374R326H1.000Damaging0.00Deleterious Decrease Deleterious
rs3202399E413K0.976Damaging0.18Tolerated Decrease Tolerated
VAR_068176R93C0.999Damaging0.01Deleterious Decrease Deleterious
VAR_026828R356Q1.000Damaging0.00Deleterious Decrease Deleterious

SNPs highlighted in bold are predicted to be deleterious.