In Silico Screening and Molecular Dynamics Simulation of Disease-Associated nsSNP in TYRP1 Gene and Its Structural Consequences in OCA3

Table 3

The 𝐺 score, 𝑃 score, molecular variations, and prediction reliability calculated from MutPred server. Here the most disease associated mutations are displayed in bold.

SNP ID	Mutation	MUTPred
		𝐺 score	𝑃 score	Molecular Variation	Prediction reliability
rs201293896	R146W	0.524	0.0566	Loss of disorder	No reliable Inference
rs149856598	G309E	0.563	0.0869	Loss of catalytic residue	No reliable inference
rs139946740	G309R	0.611	0.0971	Gain of solvent accessibility	No reliable inference
rs113146199	D343V	0.613	0.0676	Loss of disorder	No reliable inference
rs61752939	T262M	0.599	0.079	Loss of helix	No reliable inference
rs61752937	R93H	0.354	0.0986	Loss of disorder	No reliable inference
rs16929374	R326H	0.938	0.0202	Loss of stability	Confident hypothesis
VAR_026828	R356Q	0.801	0.0446	Loss of catalytic residue at R356	Confident hypothesis