Embryotoxic and Teratogenic Effects of Nickel in Swiss Albino Mice during Organogenetic Period

Table 2

Influence of Ni⁺² (as NiCl₂·6H₂O) on embryonic developmental of mice.

Parameters	Group I; (control)	Group II; (46.125 mg Ni/kg b.wt.)	Group III; (92.25 mg Ni/kg b.wt.)	Group IV; (184.5 mg Ni/kg b.wt.)
Average number of implant sites/dam (I)	8.00±0.57	8.00±0.57	7.33±0.33	6.80±1.49
Average number of live fetuses/dam (II)	8.00±0.57	7.66±0.66	6.66±0.33	4.40±0.87^∗∗
Resorbed embryos (%)	—	4.16	9.09	23.52
Dead fetuses (%)	—	—	—	5.88
Dead macerated fetuses (%)	—	—	—	5.88
Postimplantation death (%)	—	4.16	9.09	35.29
Sex ratio (M : F)	54.16 : 45.83	52.63 : 47.36	50.00 : 50.00	52.94 : 47.05
Fetal weight (gm) (III)	1.35±0.00	1.29±0.018^∗	1.18±0.022^∗∗	0.82±0.063^∗∗
Placental weight (gm) (IV)	0.12±0.002	0.10±0.003	0.10±0.004	0.09±0.004

(I) and (II) analyzed by one way Mann Whitney 𝑈-test.
(III) and (IV) analyzed by one way analysis of variance.
*Almost significant (𝑃<0.05).
**Significant (𝑃<0.01).