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BioMed Research International
Volume 2013 (2013), Article ID 702871, 9 pages
Clinical Study

Analysis of Risk Factors for First Seizure after Stroke in Chinese Patients

1Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province 250021, China
2Department of Neurology, People’s Hospital of Binzhou, Binzhou, Shandong Province 256610, China
3Department of Neurology, Jinan Military General Hospital, Jinan, Shandong Province 250031, China
4Department of Neurology, PLA General Hospital, Beijing 100853, China
5Department of Neurology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China
6Department of Neurology, Shenyang Military General Hospital, Shenyang 110015, China
7Department of Cardiovascular Functional Studies, China Meitan General Hospital, Beijing 100028, China

Received 6 May 2013; Revised 7 August 2013; Accepted 15 September 2013

Academic Editor: Elisabeth Andreadou

Copyright © 2013 Guoqing Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study is to assess related risk factors and predict early- and late-onset seizure after first-ever stroke. A total of 2474 consecutive patients with initial stroke in China from 1997 to 2007 were retrospectively investigated, in which, 24 clinical and radiological indexes were used for evaluation. Odds ratio (OR) and 95% confidence interval (CI) were calculated by logistic regression. A total of 232 (11.1%) of patients developed seizures during a mean follow-up period of 18 months, with 123 experiencing early-onset and 109 late-onset seizure. The independent risk factors for early-onset seizure were large lesion ( ), subarachnoid hemorrhage ( ), initial hyponatremia ( ), and cortical involvement ( ). The independent risk factors for late-onset seizure were cortical involvement ( ) and large lesion ( ). These results demonstrated that the risk factors for early seizure after stroke are large lesion, subarachnoid hemorrhage, and cortical involvement. Surprisingly, hyponatremia also predicts seizure in stroke patients. Cortical involvement is a major risk factor for late-onset seizure after stroke.