Schiff Base Metal Derivatives Enhance the Expression of HSP70 and Suppress BAX Proteins in Prevention of Acute Gastric Lesion
Figure 2
Microscopic study of gastric mucosa in rats (20x). Histological H&E staining of the gastric tissues (left column) and immunohistochemistry (IHC) of HSP70 and BAX proteins (mid column and right column, resp.) are shown for different experimental groups. Normal control group (1st row) shows intact gastric tissue with moderate presence of HSP70 and low presence of BAX. The ulcer control group (2nd row) shows epithelial disruption with acute hemorrhagic lesions into the mucosa. Remarkable submucosa edema and leucocyte penetration are noticeable. The presence of HSP70 is apparently suppressed while the BAX protein is considerably overwhelmed. The Schiff base derivative complexes (3rd–6th rows) show considerable protection against the mucoepithelial disruption caused by ethanol. The edema is not significant. The IHC of HSP70 and BAX shows that these proteins are meaningfully regulated by the Schiff base derivative complexes. The presence of HSP70 in considerably increased when compared to either of the control groups while that of BAX proteins is dramatically declined.
